Background: The mahogany tree (Swietenia macrophylla King) is widely used in traditional medicine, especially its seeds, which are used in Malaysia, Indonesia and some countries of South America. Recently an active fraction of the leaf ethanolic extract (labelled “Sm13-16,23”), showed promising results against some toxins of South American pit vipers.
Objectives: In this study the aim was to evaluate the acute oral toxicity of fraction Sm13-16,23 from the leaf ethanolic extract, using Swiss Webster mice.
Methods: Fraction Sm13-16,23 was administered orally in a single dose to 2000 mg/kg and 300 mg/kg, clinical follow-up for 14 days was performed and then euthanasia, necropsy and histopathology of organs were performed.
Results: Overall, there were not deaths recorded during the study period. Further not signs of toxicity in doses of 300mg/kg were observed, but at doses of 2000 mg/kg, histopathological lesions in the liver, as karyomegaly and binucleation were observed.
Conclusions: Fraction Sm13-16, 23 does not produce toxicity lesion at doses of 300mg/kg, indicating that the acute oral toxicity risk is low.
The Mahogany tree (Swietenia macrophylla King), which can usually reach 40 to 60 meters, belongs to the Meliaceae family and has a tropical distribution found in Central and South America, in Western India, in Malaysia and in the central and southern China (1,2). This plant is used in Asia for the treatment of various diseases based on their antimicrobial effects, anti-inflammatory, antioxidant, anti-mutagenic, anti-cancer, anti-tumor and anti-diabetic activities (2). Its seeds have many uses, such as in the traditional treatment of hypertension, diabetes and to relieve pain in Malaysia, to treat leishmaniosis and to induce abortion in Bolivia, as well as for the treatment of diabetes, hypertension and malaria in Indonesia. In addition, its bark is used as an astringent for wounds and occasionally for sun tanning (2-6).