مقاله انگلیسی ویژگی های جنسی در علائم اضطراب و افسردگی در طول عمر
ترجمه نشده

مقاله انگلیسی ویژگی های جنسی در علائم اضطراب و افسردگی در طول عمر

عنوان فارسی مقاله: ویژگی های جنسی در علائم اضطراب و افسردگی در طول عمر و ارتباط آنها با تصویربرداری عصبی چندوجهی
عنوان انگلیسی مقاله: Sex-specificities in anxiety and depressive symptoms across the lifespan and their links with multimodal neuroimaging
مجله/کنفرانس: مجله اختلالات عاطفی - Journal of Affective Disorders
رشته های تحصیلی مرتبط: روانشناسی
گرایش های تحصیلی مرتبط: روانشناسی بالینی و روانشناسی عمومی
کلمات کلیدی فارسی: سلامت روان، سالخورده، آتروفی، متابولیسم گلوکز، رسوب آمیلوئید
کلمات کلیدی انگلیسی: Mental health - Ageing - Atrophy - Glucose metabolism - Amyloid deposition
نوع نگارش مقاله: مقاله پژوهشی (Research Article)
شناسه دیجیتال (DOI): https://doi.org/10.1016/j.jad.2021.10.004
دانشگاه: Department of Clinical Research, Caen Normandy Hospital (CHU) de Caen, France
صفحات مقاله انگلیسی: 10
ناشر: الزویر - Elsevier
نوع ارائه مقاله: ژورنال
نوع مقاله: ISI
سال انتشار مقاله: 2021
ایمپکت فاکتور: 4.839 در سال 2020
شاخص H_index: 188 در سال 2020
شاخص SJR: 1.892 در سال 2020
شناسه ISSN: 0165-0327
شاخص Quartile (چارک): Q1 در سال 2020
فرمت مقاله انگلیسی: PDF
وضعیت ترجمه: ترجمه نشده است
قیمت مقاله انگلیسی: رایگان
آیا این مقاله بیس است: بله
آیا این مقاله مدل مفهومی دارد: ندارد
آیا این مقاله پرسشنامه دارد: ندارد
آیا این مقاله متغیر دارد: دارد
آیا این مقاله فرضیه دارد: ندارد
کد محصول: E15775
رفرنس: دارای رفرنس در داخل متن و انتهای مقاله
فهرست مطالب (انگلیسی)

Abstract
Keywords
Background
Methods
Results
Discussion
Conclusion
Declarations of Competing Interest
Acknowledgments
Appendix. Supplementary materials
References

بخشی از مقاله (انگلیسی)

ABSTRACT
Background: Anxiety and depressive symptoms are associated with impaired well-being, higher risk of developing psychoaffective disorders and are risk factors for Alzheimer’s disease (AD). To further understand their relevance and the mechanisms underlying their link with AD, our aims were to assess how anxiety and depressive symptoms changed with age and related to AD neuroimaging biomarkers across the adult lifespan, while also exploring sex specificities. Methods: 210 cognitively normal participants aged 19-86 years (101 men, 109 women) completed assessments of anxiety and depressive symptoms with the STAI-A and MADRS respectively, and neuroimaging measurements including structural MRI, FDG-PET and amyloid-PET. 167 of those were followed-up over 1.5–3 years. Multiple regressions were performed to assess the links between anxiety or depressive symptoms versus age, global cognition or each imaging modality, both cross-sectionally and longitudinally; and general linear models we used to test the interactive effect of sex on these associations. Results: Depressive symptoms decreased with age, while anxiety symptoms increased only among women. Higher anxiety symptoms were associated with lower grey matter (GM) volume and glucose metabolism, with an interaction of sex, this relationship being significant only in women. Longitudinally, only low baseline GM volume predicted an increase in anxiety symptoms with time. Limitations: Only 43% of participants reported depressive symptoms. Despite additional analyses, the low variability in the measure might have prevented us from detecting subtle changes. Conclusions: This study emphasizes the need to consider anxiety symptoms in assessments for dementia risk, particularly in women. 
Background
Subclinical symptoms of anxiety and depression are frequently observed in older adults (Bryant et al., 2008; Forlani et al., 2014), and are associated with a high risk of developing anxiety and depressive disorders (Chambers et al., 2004; Cuijpers and Smit, 2004; Karsten et al., 2011). Elevated levels of anxiety and depression are associated with a worsening of the quality of life of seniors, fragility, sleep problems and cognitive disorders, or even with increased rates of mortality, morbidity and disability (Bryant et al., 2008; Cuijpers and Smit, 2004; Siegel and Mathews, 2015). Moreover, subthreshold anxiety and depressive symptoms were found to increase the risk of developing dementia (Harrington et al., 2015; Petkus et al., 2016; Singh-Manoux et al., 2017). Compared to individuals without symptoms of anxiety and depression, they were twice as likely to develop amnestic Mild Cognitive Impairment (MCI), a prodromal phase of Alzheimer’s dementia, over 3–6 years (Donovan et al., 2018).