تولید تخمیری پروتوپاناکسادیول
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تولید تخمیری پروتوپاناکسادیول

عنوان فارسی مقاله: فرآیند زیستی یکپارچه برای تولید تخمیری پروتوپاناکسادیول توسط بازیافت زباله اتانول در طی فرآیند استخراج جریان پایین
عنوان انگلیسی مقاله: An integrated bioprocess for fermentative production of protopanaxadiol by recycling ethanol waste during down-stream extraction process
مجله/کنفرانس: مجله تولید پاک – Journal of Cleaner Production
رشته های تحصیلی مرتبط: زیست، شیمی
گرایش های تحصیلی مرتبط: بیوشیمی، شیمی محیط زیست
کلمات کلیدی فارسی: فرآیند زیستی یکپارچه، پروتوپاناکسادیول، تخمیر، بازیابی حلال آلی، ساکارومایسس سرویزیا
کلمات کلیدی انگلیسی: Integrated bioprocess، Protopanaxadiol، Fermentation، Organic solvent recovery، Saccharomyces cerevisiae
نوع نگارش مقاله: مقاله پژوهشی (Research Article)
نمایه: Scopus – Master Journals List – JCR
شناسه دیجیتال (DOI): https://doi.org/10.1016/j.jclepro.2019.06.190
دانشگاه: School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300350, PR China
ناشر: الزویر - Elsevier
نوع ارائه مقاله: ژورنال
نوع مقاله: ISI
سال انتشار مقاله: 2019
ایمپکت فاکتور: 7.096 در سال 2018
شاخص H_index: 150 در سال 2019
شاخص SJR: 1.620 در سال 2018
شناسه ISSN: 0959-6526
شاخص Quartile (چارک): Q1 در سال 2018
فرمت مقاله انگلیسی: PDF
تعداد صفحات مقاله انگلیسی: 8
وضعیت ترجمه: ترجمه نشده است
قیمت مقاله انگلیسی: رایگان
آیا این مقاله بیس است: خیر
آیا این مقاله مدل مفهومی دارد: ندارد
آیا این مقاله پرسشنامه دارد: ندارد
آیا این مقاله متغیر دارد: ندارد
کد محصول: E12691
رفرنس: دارای رفرنس در داخل متن و انتهای مقاله
فهرست انگلیسی مطالب

Abstract


1-Introduction


2-Materials and methods


3-Results and discussion


4-Conclusion


Conflicts of interest


Acknowledgements


Appendix A. Supplementary data


References

نمونه متن انگلیسی مقاله

Abstract


Solvent recovery and reutilization in bioprocess have great potential to reduce production cost and environmental harm. However, solvent recovery process is often energy-intensive and costly. In this study, we developed an integrated bioprocess for fermentative production of protopanaxadiol (PPD) from ethanol waste recycled in down-stream extraction process, achieving solvent recovery and reutilization in a cost-effective manner. In this integrated process, PPD isolation and purification were achieved by foam separation and resin chromatography, respectively; ethanol solution used as PPD extractant and chromatography eluent was recycled to be reused directly as yeast carbon source for PPD biosynthesis. Notably, in 3 batches of 5 L-fermentation productions, the recycled ethanol could compensate 81.3% of the ethanol used in fermentation. Since the lost PPD during chromatography elution was returned into the next-batch fermentation together with the recycled ethanol, the overall yield of 3- batch production (85.78%) was higher than the yield of single batch production (~75%). This study demonstrates a promising integrated bioprocess for triterpene compounds production from ethanol waste.


Introduction


Protopanaxadiol (PPD), a major bioactive component of Panax ginseng, is regarded as promising high-value pharmaceutical compound for tumor inhibition and depression treatment (Li et al., 2006; Popovich and Kitts, 2004; Hui et al., 2012b). Traditional PPD production relies on phytoextraction that is followed by hydrolysis or enzymolysis, and is a labor-intensive and highly polluting process. Synthetic biology technology provides an alternative method for producing PPD in engineered Saccharomyces cerevisiae (S. cerevisiae) (Xu et al., 2013). In recent years, considerable progress has been achieved for engineering yeast for high production of PPD (Dai et al., 2013; Zhao et al., 2016, 2017). However, the down-stream bioprocess of PPD isolation and purification has not yet been studied. The down-stream bioprocess is known to be relatively solvent intensive. It has been reported that for the production of 1 kg of commercially available active pharmaceutical ingredients a median value of 45 kg of material needs to be used, of which about 50% has been organic solvents (Henderson et al., 2007). Recovery of waste solvent through crystallization or membrane separation can offer significant benefits with regards to reduced storage and waste costs as well as increased compliance with environmental legislation. However, these recovery processes are highly energy-intensive and costly (Constable et al., 2007). Therefore, it is of great interest to find a new way to reutilize the wasted organic solvent to be recycled during down-stream bioprocess.

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