تحلیل داده های دارویی زنان مبتلا به فیبروم رحمی
ترجمه نشده

تحلیل داده های دارویی زنان مبتلا به فیبروم رحمی

عنوان فارسی مقاله: تجزیه و تحلیل داده های دارویی زنان مبتلا به فیبروم رحمی بر اساس فناوری داده کاوی
عنوان انگلیسی مقاله: Analysis of medication data of women with uterine fibroids based on data mining technology
مجله/کنفرانس: مجله عفونت و سلامت عمومی - Journal Of Infection And Public Health
رشته های تحصیلی مرتبط: پزشکی، مهندسی صنایع
گرایش های تحصیلی مرتبط: جراحی زنان و زایمان، داده کاوی
کلمات کلیدی فارسی: فیبروم رحم، داده کاوی، درمان پزشکی، Mifepristone، دانازول
کلمات کلیدی انگلیسی: Uterine fibroids، Data mining، Medical treatment، Mifepristone، Danazol
نوع نگارش مقاله: مقاله پژوهشی (Research Article)
نمایه: MedLine - DOAJ - Scopus - Master Journals List - JCR
شناسه دیجیتال (DOI): https://doi.org/10.1016/j.jiph.2019.07.017
دانشگاه: Department of Gynaecology, Maternal and Child Health Hospital of Foshan, No. 11 Renmin West Road, Chancheng District, Foshan City, 528000, Guangdong Province, China
ناشر: الزویر - Elsevier
نوع ارائه مقاله: ژورنال
نوع مقاله: ISI
سال انتشار مقاله: 2019
ایمپکت فاکتور: 2/485 در سال 2018
شاخص H_index: 25 در سال 2019
شاخص SJR: 0/899 در سال 2018
شناسه ISSN: 1876-0341
شاخص Quartile (چارک): Q2 در سال 2018
فرمت مقاله انگلیسی: PDF
تعداد صفحات مقاله انگلیسی: 4
وضعیت ترجمه: ترجمه نشده است
قیمت مقاله انگلیسی: رایگان
آیا این مقاله بیس است: خیر
آیا این مقاله مدل مفهومی دارد: ندارد
آیا این مقاله پرسشنامه دارد: ندارد
آیا این مقاله متغیر دارد: ندارد
کد محصول: E13012
رفرنس: دارای رفرنس در داخل متن و انتهای مقاله
فهرست انگلیسی مطالب

Abstract


Introduction


Research contents


Research results


Conclusion


References

نمونه متن انگلیسی مقاله

Abstract


The purpose of this study was to analyze the characteristics of the diagnosis and treatment of female uterine fibroids based on data mining technology and the medication rule. Clinical literature related to the treatment of uterine fibroids by Chinese National Knowledge Infrastructure (CNKI) from 2004 to 2018 were searched, and the literature meeting the requirements were selected according to the inclusion criteria and exclusion criteria. The contents of the prescription were recorded into the database, and the results of drug frequency, common drugs and core rules, etc. were obtained by the rule analysis of the software, so as to analyze the medication rules of modern doctors in treating uterine fibroids. Through research and analysis, it showed that common clinical drugs include leuprorelin (GnRH-a), danazol (androgen), gestrinone (progestin), mifepristone (progesterone receptor antagonist), and some cases of combination therapy. Based on the analysis of the frequency of drug, treatment effect and adverse drug reactions, it was found that the clinical application of mifepristone in the treatment of uterine fibroids was relatively common, with significant drug effect and mild adverse reactions, which was worthy of clinical promotion and application. Therefore, the results of this study provide a new basis for the clinical and basic research of traditional Chinese medicine in the treatment of uterine fibroids, but it still needs the verification of expert interpretation, experimental research and other methods.


Introduction


Uterine fibroids are one of the most common benign tumors in women and are derived from the monoclonal proliferation of uterine smooth muscle cells. Uterine fibroids are more common in women of childbearing age and are greatly affected by estrogen and progesterone. The incidence of uterine fibroids is related to race, with the highest incidence among African Americans, accounting for 80% [1]. In addition, the high-risk factors of fibroids also include age, early menarche, late childbirth, coffee, alcohol abuse, gene mutation, obesity and other problems [2]. There are a variety of clinical manifestations of uterine fibroids, including menorrhagia, prolonged menstruation, pain, anemia, abortion, infertility, abnormal band, bladder and rectal compression symptoms. Uterine fibroids will not only affect the fertility of patients, but also affect the quality of life and psychological status of patients. In terms of infertility, infertility caused by uterine fibroids alone accounts for less than 3% of all infertile patients [3,4]. Studies have shown that normal tissue around the uterus in patients with uterine fibroids contains significantly less estrogen and progesterone receptors than fibroids. In patients with uterine fibroids, the normal tissue surrounding the uterus contains significantly reduced estrogen and progesterone receptors than in fibroid tissue.In 2014,the state food and drug administration has approved Mifepristone (RU486), gonadotropin-releasing hormone agonist (GnRH-a), gossypol and some traditional Chinese medicines for the treatment of uterine fibroids [5,6]. Recent studies have shown that mifepristone not only directly inhibits follicular development and secretion in the ovary, but also may inhibit the secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH). Therefore, the drugs commonly used in the clinical treatment of uterine fibroids are drugs that can reduce the level of estrogen and progesterone. For example, the use of gonadotropin receptor agonists.

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