رابطه وضعیت استیل کولین استراز با آسیب پذیری اعتیاد به مواد مخدر
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رابطه وضعیت استیل کولین استراز با آسیب پذیری اعتیاد به مواد مخدر

عنوان فارسی مقاله: ارتباط وضعیت استیل کولین استراز و انواع ۳’ UTR ژن ACHE با آسیب پذیری اعتیاد به مواد مخدر در جمعیت پاکستان
عنوان انگلیسی مقاله: Association of status of acetylcholinesterase and ACHE gene 3’ UTR variants (rs17228602, rs17228616) with drug addiction vulnerability in pakistani population
مجله/کنفرانس: تعاملات شیمیایی-بیولوژیکی - Chemico-biological Interactions
رشته های تحصیلی مرتبط: شیمی، زیست
گرایش های تحصیلی مرتبط: شیمی آلی، شیمی کاربردی، بیوشیمی، علوم سلولی و مولکولی
کلمات کلیدی فارسی: استیل کولین استراز، ACHE، اعتیاد، هروئین، چندریختی تک-نوکلئوتید، انواع ۳′UTR
کلمات کلیدی انگلیسی: Acetylcholinesterase، ACHE، Addiction، Heroin، SNP، ۳′UTR variants
نوع نگارش مقاله: مقاله پژوهشی (Research Article)
نمایه: MedLine - Scopus - Master Journals List - JCR
شناسه دیجیتال (DOI): https://doi.org/10.1016/j.cbi.2019.05.036
دانشگاه: Department of Biosciences, COMSATS University Islamabad, Islamabad, Pakistan
ناشر: الزویر - Elsevier
نوع ارائه مقاله: ژورنال
نوع مقاله: ISI
سال انتشار مقاله: 2019
ایمپکت فاکتور: 3/453 در سال 2018
شاخص H_index: 108 در سال 2019
شاخص SJR: 0/923 در سال 2018
شناسه ISSN: 0009-2797
شاخص Quartile (چارک): Q2 در سال 2018
فرمت مقاله انگلیسی: PDF
تعداد صفحات مقاله انگلیسی: 7
وضعیت ترجمه: ترجمه نشده است
قیمت مقاله انگلیسی: رایگان
آیا این مقاله بیس است: خیر
آیا این مقاله مدل مفهومی دارد: ندارد
آیا این مقاله پرسشنامه دارد: ندارد
آیا این مقاله متغیر دارد: ندارد
کد محصول: E13188
رفرنس: دارای رفرنس در داخل متن و انتهای مقاله
فهرست انگلیسی مطالب

Abstract


1- Introduction


2- Material and methods


3- Results


4- Discussion


5- Conclusion


References

نمونه متن انگلیسی مقاله

Abstract


Substance addiction is a chronic, relapsing mental disorder Characterized by compulsive drug seeking, and loss of control over drug intake and relapse after prolonged abstinence. Genetics has been shown to contribute towards an individual's vulnerability to addiction. Acetylecholine (ACh), a cholinergic neurotransmitter hydrolyzed by acetylcholinesterase (AChE), is an essential neurotransmitter and neuromodulator in central and peripheral nervous system and has regulatory influence on numerous neuronal functions including addiction. The present study was carried out to investigate the role of acetylcholinesterase (AChE) in addiction through measurement of enzyme activity and to find potential association of ACHE gene 3′UTR variants rs17228602 and rs17228616 in heroin, hashish and poly drug addicts. Both SNPs are located within microRNA (miRNA) recognition sites with potential to affect miRNA/transcript interaction. A total of 122 addicts of heroin, hashish and polydrug were recruited from local rehabilitation centers to participate in this study. AChE activity was measured in blood by Ellman's method. SNP genotyping was performed by restriction fragment length polymorphism (PCR-RFLP) and Sanger sequencing. The AChE activity was found significantly higher (p ≤ 0.005) in addicted cohort (mean ± standard error of mean 0.020 ± 0.001 μmol/L/min; 95% confidence interval (CI) 0.018–0.022) in comparison to non-addicted healthy subjects (0.011 ± 0.001 μmol/L/min; 95% confidence interval CI 0.010–0.013). A statistically significant association of ACHE rs17228602 SNP with addiction vulnerability in dominant (DM: Odd's ratio OR = 2.095, 95% CI = 1.157–3.807 p = 0.009) and allelic genetic models (OR = 1.854 95% CI = 1.082–3.187, p = 0.016) was observed. However, no statistically significant association of rs17228616 SNP with substance abuse disorder was found. The data presented here shows that AChE could play significant role in substance addiction. Further studies with larger sample size and other variants of AChE are recommended to identify novel therapeutic approaches for cholinergic based treatment of addiction.


Introduction


Drug addiction is a persistent relapsing mental disorder encompassing uncontrollable drug use and severe emotional impairment. Repeated intake of illicit drugs changes several brain regions making drug seeking a compulsive and sole purpose of addict's life, eventually harming the physiological and physical well-being of the addicted individual [1,2]. There are many substances that can lead to addiction if used excessively including but not limited to heroin, alcohol, cocaine, cannabis, ice and opioids [3]. Worldwide estimates put the number of addicts to an estimated 27.8 million according to United Nations Office of Drugs and Crime (UNODC). In Pakistan, around 6.7 million people have been reported to abuse drugs at least once in their life and, 4.25 million of them became heroin dependent according to 2013 UNODC report. Due to considerable morbidity and mortality, drug addiction is a serious socioeconomic concern besides spreading many infectious diseases like hepatitis B and C, HIV etc. It is also associated with psychiatric disorders like anxiety and depression. Drug addiction is a multifactorial disorder involving genetics, epigenetics, environment, type of illicit drugs, route of drug administration, physiological and socioeconomic factors [4].

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