سازگاری های مفید ناشی از ورزش
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سازگاری های مفید ناشی از ورزش

عنوان فارسی مقاله: نه اتوفاژی و نه حالت تمرین ورزشی بر سازگاری های مفید ناشی از ورزش در موش های دارای چربی بالا تأثیر نمی گذارند
عنوان انگلیسی مقاله: Neither autophagy nor exercise training mode affect exercise-induced beneficial adaptations in high fat-fed mice
مجله/کنفرانس: پزشکی ورزشی و علوم بهداشتی – Sports Medicine and Health Science
رشته های تحصیلی مرتبط: تربیت بدنی
گرایش های تحصیلی مرتبط: فیزیولوژی ورزشی، فیزیولوژی فعالیت بدنی و تندرستی، فیزیولوژی فعالیت ورزشی بالینی
کلمات کلیدی فارسی: مقاومت به انسولین، ظرفیت ورزشی، تحمل گلوکز، چاقی
کلمات کلیدی انگلیسی: Insulin resistance، Exercise capacity، Glucose tolerance، Obesity
نوع نگارش مقاله: مقاله پژوهشی (Research Article)
شناسه دیجیتال (DOI): https://doi.org/10.1016/j.smhs.2020.03.003
دانشگاه: Integrative Muscle Metabolism Laboratory, Exercise Science Research Center, Department of Human Health Performance and Recreation, University of Arkansas, USA
ناشر: الزویر - Elsevier
نوع ارائه مقاله: ژورنال
نوع مقاله: ISI
سال انتشار مقاله: 2020
شناسه ISSN: 2666-3376
فرمت مقاله انگلیسی: PDF
تعداد صفحات مقاله انگلیسی: 10
وضعیت ترجمه: ترجمه نشده است
قیمت مقاله انگلیسی: رایگان
آیا این مقاله بیس است: خیر
آیا این مقاله مدل مفهومی دارد: ندارد
آیا این مقاله پرسشنامه دارد: ندارد
آیا این مقاله متغیر دارد: ندارد
کد محصول: E15035
رفرنس: دارای رفرنس در داخل متن و انتهای مقاله
فهرست انگلیسی مطالب

Abstract


Introduction


Methods


Results


Discussion


Conflict of interest


Submission statement


Authors’ contributions


Acknowledgments


References

نمونه متن انگلیسی مقاله

Abstract


Exercise mitigates obesity-associated pathologies; however, there is controversy regarding optimal exercise interventions. Autophagy, is known to decrease during obesity and is an important moderator for exercise adaptations. Purpose: To investigate individual and combined effects of different exercise interventions and autophagy inhibition on exercise adaptations during obesity. Methods: C57BL/6J mice initiated 45% high fat diet at 8 weeks of age. After 6 weeks of diet, animals were divided into moderate (MOD) or high intensity interval training interventions (HIIT), animals were further divided into autophagy inhibition or vehicle conditions (n ¼ ۱۰/group). Animals exercised and autophagy was inhibited 3X/ week by NSC185058 injections, thereby blocking autophagosome formation. Interventions continued for 4 weeks. Results: High fat diet impaired glucose handling ~17%; exercise interventions normalized glucoregulation to prehigh fat diet levels, without differences between any interventions. High fat diet induced ~25% decrease in aerobic capacity, which returned to baseline after exercise interventions, with no differences between any interventions. No effects of autophagy inhibition were noted. Conclusions: HIIT and MOD training confer similar health-related adaptations.


Introduction


Obesity, metabolic syndrome, and type 2 diabetes mellitus (T2DM) remain significant maladies in Western society.1 Insulin medication costs have more than doubled, causing significant economic burdens and a reduction in overall quality of life for millions of patients.2 Exercise is known to decrease T2DM-associated insulin resistance (IR) and mortality regardless of weight loss.3 Recently, controversy surrounding the relative effectiveness of high intensity interval training (HIIT) compared to moderate intensity continuous training (MOD) has emerged.4 HIIT has become exponentially more popular over the past decade, finishing in the top three fitness trends in each of the last five years.5 Clinically, HIIT has become increasingly widespread as an exercise intervention across a greater breadth of populations, including those with metabolic impairments.4,6–۹ More so, recent meta-analyses suggest HIIT to be more effective compared to traditional moderate intensity continuous training (MOD) to improve insulin sensitivity.10 However, mechanisms that may correspond to the purported augmented benefits have yet to be elucidated. More so, it is difficult to draw strong conclusions regarding any potential additional benefits associated with HIIT compared to MOD, as many “comparative” protocols in the past did not match total work completed or average intensity of exercise.7,11,12 One cellular mechanism recently implicated in the development of exercise adaptations is autophagy.13–۱۵ Autophagy is a process that removes dysfunctional cellular components by sequestering organelles within an autophagosome and degrading them by lysosomal reaction.16 Previous research has demonstrated reductions in autophagy during IR.17,18 and transgenic models blocking autophagy initiation demonstrate diminished glucose handling capacity compared to healthy controls.19 Additionally, inhibition of Beclin-mediated autophagy impairs exercise training adaptations in otherwise healthy mice.20 Conversely, exercise interventions are known to increase autophagy.20–۲۲ Yet, the precise stimuli needed to activate autophagy with exercise training and the subsequent effects on IR remain uninvestigated, specifically the exercise intensity or volume necessary to induce adaptations.

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