مشارکت ورزشی و هوشیاری در کودکان
Abstract
1- Introduction
2- Methods
3- Results
4- Discussion
5- Conclusion
Acknowledgments
References
Abstract
Background: Idiopathic pulmonary fibrosis (IPF) is characterized by progressive impairment of lung function and degradation of daily activity; however, this degradation has not been adequately elucidated. The objective of this study was to measure the physical activity of patients with IPF to determine its relationships with physiological parameters and survival rate. Methods: In total, 31 patients with IPF and 20 age-matched healthy participants were enrolled in this study. Physical activity was assessed using a physical activity monitor. The relationships among physical activity, physiological data, questionnaire-based patient-centered data, and survival were examined. Results: Physical activity, expressed as daily activity energy expenditure (AEE), was significantly lower, and the percentage of sedentary time was significantly longer in patients with IPF than in healthy participants. Moreover, AEE was moderately correlated with body-mass index, forced vital capacity, diffusing capacity of carbon monoxide, and partial arterial pressure of oxygen. Relatively strong correlation was also observed between AEE and the 6-min walk distance, but not with daily dyspnea, depression, and health-related quality of life scores. Prognostic analysis indicated that daily AEE was a significant predictor of survival. Conclusions: Patients with IPF were significantly inactive compared with age-matched healthy participants. In patients with more impaired physiological functions, the lower the physical activity was, the more was the sedentary time increased. Furthermore, lower daily physical activity resulted in significantly worse survival.
Introduction
Idiopathic pulmonary fibrosis (IPF) is a debilitating disease that is characterized by progressive impairment in lung function and degradation of daily activity. Lung function, such as forced vital capacity (FVC), is now recognized as one of the important outcomes in clinical trials and cohort studies of IPF, because it significantly predicts survival [1]. Exercise capacity, such as a 6-min walk distance (6MWD) and maximal oxygen consumption measured by a cardiopulmonary exercise test, is decreased in IPF and is considered a significant predictor of survival [2–4]. However, the actual daily life physical activity in patients with IPF has not been adequately elucidated. Recently, physical activity has been of focal interest in chronic obstructive pulmonary disease (COPD) [5]. Patients with COPD have reduced physical activity, which is not completely reflected by the disease severity when determined via the lung function [6,7]. More importantly, physical activity is reportedly a stronger predictor of survival than is forced expiratory volume in 1 sec (FEV1) and exercise capacity assessed by a 6-min walk test (6MWT) [8]. The question remains as to whether the reduction in physical activity due to IPF is similar to that in COPD and is associated with the survival rate. To address this, patients with IPF and age-matched healthy participants were prospectively recruited, and physical activity was measured to determine its relationship with physiological parameters and survival rate.