ترویج استقلال در زوال عقل با اجسام لوئی از طریق ورزش
ترجمه نشده

ترویج استقلال در زوال عقل با اجسام لوئی از طریق ورزش

عنوان فارسی مقاله: ارتقاء استقلال در زوال عقل با اجسام لوئی از طریق ورزش (PRIDE): پروتکل برای یک مطالعه مقدماتی
عنوان انگلیسی مقاله: Promoting independence in Lewy body dementia through exercise (PRIDE) study: Protocol for a pilot study
مجله/کنفرانس: ارتباطات کارآزمایی بالینی معاصر - Contemporary Clinical Trials Communications
رشته های تحصیلی مرتبط: تربیت بدنی
گرایش های تحصیلی مرتبط: فیزیولوژی ورزشی، فیزیولوژی فعالیت بدنی و تندرستی، فیزیولوژی فعالیت ورزشی بالینی، روانشناسی ورزشی
کلمات کلیدی فارسی: جسم لویی، زوال عقل، ورزش، آنابوليک، عملکرد مستقل
کلمات کلیدی انگلیسی: Lewy body، Dementia، Exercise، Anabolic، Functional independence
نوع نگارش مقاله: مقاله پژوهشی (Research Article)
نمایه: Scopus - Master Journals List - DOAJ - PubMed Central
شناسه دیجیتال (DOI): https://doi.org/10.1016/j.conctc.2019.100466
دانشگاه: The University of Sydney Faculty of Health Sciences, Discipline of Exercise and Sports Science, Cumberland Campus, Lidcombe, NSW, 2141, Australia
ناشر: الزویر - Elsevier
نوع ارائه مقاله: ژورنال
نوع مقاله: ISI
سال انتشار مقاله: 2019
ایمپکت فاکتور: 1/005 در سال 2019
شاخص H_index: 6 در سال 2020
شاخص SJR: 0/453 در سال 2019
شناسه ISSN: 2451-8654
شاخص Quartile (چارک): Q3 در سال 2019
فرمت مقاله انگلیسی: PDF
تعداد صفحات مقاله انگلیسی: 22
وضعیت ترجمه: ترجمه نشده است
قیمت مقاله انگلیسی: رایگان
آیا این مقاله بیس است: بله
آیا این مقاله مدل مفهومی دارد: ندارد
آیا این مقاله پرسشنامه دارد: ندارد
آیا این مقاله متغیر دارد: ندارد
کد محصول: E14926
رفرنس: دارای رفرنس در داخل متن و انتهای مقاله
فهرست مطالب (انگلیسی)

Abstract


1- Introduction


2- Materials and methods


3- Discussion


References

بخشی از مقاله (انگلیسی)

Abstract


Background: Lewy Body dementia (LBD) is the second most prevalent neurodegenerative dementia. This form of dementia is notable for an aggressive disease course consisting of a combination of cognitive, Parkinsonian, affective, and physiological symptoms that significantly increase morbidity and mortality, and decrease life expectancy in this population compared to more common dementias. Additionally, those diagnosed with LBD are often excluded from trials evaluating exercise in similar diseases such as Alzheimer’s disease or Parkinson’s disease due to the complexity and concurrency of motor and cognitive symptoms. Consequently, there is scarce research evaluating the effect of exercise on individuals with LBD.
Methods: The PRomoting Independence in Lewy Body Dementia through Exercise (PRIDE) trial is a novel non-randomised, crossover pilot study consisting of an 8-week wait-list usual care period, followed by an 8-week exercise intervention targeting progressive resistance and balance training. The trial aim is to evaluate the effect of exercise on the primary outcome of functional independence and secondary outcomes including cognitive, physical, psychosocial and quality of life measures in people living with LBD and their caregivers. The intervention involves 3 supervised 1-hour sessions per week (24 sessions in total) administered by an Accredited Exercise Physiologist in a clinical facility at the University of Sydney in Lidcombe, Australia.
Discussion: The PRIDE study is the first controlled trial to evaluate a robust exercise intervention within a LBD cohort and will provide crucial information required to inform robust future clinical trials.


Introduction


Lewy body dementia (LBD) is an umbrella term for the diseases of dementia with Lewy bodies (DLB), and Parkinson’s disease dementia (PDD) which share common pathology, and have a variable estimated prevalence of up to 24% of all dementia diagnosis(1). LBD has complex, fluctuating symptomatology, including parkinsonism, psychosis, autonomic and cognitive impairments; with afflicted individuals progressing more rapidly to residential care and death following diagnosis(2). The prevalence of frailty in early LBD (37%) is double that of Alzheimer’s disease (AD) or Parkinson’s disease (PD)(3, 4), and strongly associated with neuropsychiatric disturbances, poorer prognosis, lower quality of life and ultimately a reduction in functional independence(2). Importantly, the rapid development of frailty in LBD is only minimally attributable to disease pathophysiology itself(5), with a greater involvement stemming from potentially treatable and highly prevalent risk factors in LBD including malnutrition, sarcopenia, delirium, infection, polypharmacy, injurious falls and behavioural disturbances(6-11). However, current treatments for LBD are predominantly pharmacological with significant risk of adverse outcomes, and do not effectively address the development of these risk factors or frailty in this cohort(12, 13).

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