مقاله انگلیسی پیش داروی پلیمری حساس به GSH
ترجمه نشده

مقاله انگلیسی پیش داروی پلیمری حساس به GSH

عنوان فارسی مقاله: پیش داروی پلیمری حساس به GSH: سنتز و بارگذاری با حساسیت به نور به عنوان نانو پزشکی ضد سرطان شیمی فوتوتینامیک در مقیاس نانو
عنوان انگلیسی مقاله: GSH-sensitive polymeric prodrug: Synthesis and loading with photosensitizers as nanoscale chemo-photodynamic anti-cancer nanomedicine
مجله/کنفرانس: Acta Pharmaceutica Sinica B
رشته های تحصیلی مرتبط: پزشکی، داروسازی
گرایش های تحصیلی مرتبط: رادیولوژی، نانو فناوری دارویی
کلمات کلیدی فارسی: پاسخ پذیری محرک ، پیش داروی پلیمری ، درمان فتودینامیکی ، درمان ترکیبی ، پزشکی نانو
کلمات کلیدی انگلیسی: Stimuli responsiveness, Polymeric prodrug, Photodynamic therapy, Combinational therapy, Nanomedicine
نوع نگارش مقاله: مقاله پژوهشی (Research Article)
شناسه دیجیتال (DOI): https://doi.org/10.1016/j.apsb.2021.05.003
دانشگاه: Sichuan University, China
صفحات مقاله انگلیسی: 34
ناشر: الزویر - Elsevier
نوع ارائه مقاله: ژورنال
نوع مقاله: ISI
سال انتشار مقاله: 2021
ایمپکت فاکتور: 10.621 در سال 2020
شاخص H_index: 51 در سال 2021
شاخص SJR: 1.912 در سال 2020
شناسه ISSN: 2211-3835
شاخص Quartile (چارک): Q1 در سال 2020
فرمت مقاله انگلیسی: PDF
وضعیت ترجمه: ترجمه نشده است
قیمت مقاله انگلیسی: رایگان
آیا این مقاله بیس است: بله
آیا این مقاله مدل مفهومی دارد: دارد
آیا این مقاله پرسشنامه دارد: ندارد
آیا این مقاله متغیر دارد: ندارد
کد محصول: E15482
رفرنس: دارای رفرنس در داخل متن و انتهای مقاله
نوع رفرنس دهی: vancouver
فهرست مطالب (انگلیسی)

Abstract

Graphical abstract

Keywords

1. Introduction

2. Materials and methods

3. Results and discussion

4. Conclusions

Author contributions

Declaration of Competing Interest

Acknowledgments

Appendix A. Supplementary data

References

بخشی از مقاله (انگلیسی)

Abstract

Precisely delivering combinational therapeutic agents has become a crucial challenge for anti-tumor treatment. In this study, a novel redox-responsive polymeric prodrug (MW: 93.5 kDa) was produced by reversible addition-fragmentation chain transfer (RAFT) polymerization. The amphiphilic block polymer-doxorubicin (DOX) prodrug was employed to deliver a hydrophobic photosensitizer (PS), chlorin e6 (Ce6), and the as-prepared nanoscale system [NPs(Ce6)] was investigated as a chemo-photodynamic anti-cancer agent. The glutathione (GSH)-cleavable disulfide bond was inserted into the backbone of the polymer for biodegradation inside tumor cells, and DOX conjugated onto the polymer with a disulfide bond was successfully released intracellularly. NPs(Ce6) released DOX and Ce6 with their original molecular structures and degraded into segments with low MWs of 41.2 kDa in the presence of GSH. NPs(Ce6) showed a chemo-photodynamic therapeutic effect to kill 4T1 murine breast cancer cells, which was confirmed from a collapsed cell morphology, a lifted level in the intracellular reactive oxygen species, a reduced viability and induced apoptosis. Moreover, ex vivo fluorescence images indicated that NPs(Ce6) retained in the tumor, and exhibited a remarkable in vivo anticancer efficacy. The combinational therapy showed a significantly increased tumor growth inhibition (TGI, 58.53%). Therefore, the redox-responsive, amphiphilic block polymeric prodrug could have a great potential as a chemo-photodynamic anti-cancer agent.

 

1. Introduction

Chemotherapy is generally considered to be one of the most efficient methods for antitumor therapy, while photodynamic therapy (PDT), which uses light to excite photosensitizers (PSs) to generate reactive oxygen species (ROS) for oxidizing intracellular biomacromolecules to induce the death of tumor cells, offers minimal invasive treatment for assisting in chemotherapy1,2. However, a low antitumor efficiency and severe systemic toxic effects of chemotherapeutics and poor water solubility and insufficient tumor accumulation of PDT agents have hampered their application3. To overcome these challenges, nanomedicines derived from liposomes, micelles, nanoparticles, dendrimers and other polymers have been applied as drug delivery systems (DDSs) for anti-tumor agents4, 5, 6, 7, 8, 9, 10. These nanomedicines have improved their accumulation owing to the enhanced permeability and retention (EPR) effect, which can decrease side effects and enhance therapeutic efficacies11, 12, 13, 14. Among these reported systems, functional polymers in response to the tumor microenvironment have been designed as smart DDSs with great potential for cancer diagnosis and therapy.