مقاله انگلیسی بررسی تأثیر بیماری های قلبی عروقی بر پاتوژنز سرطان
Abstract
Keywords
Introduction
Common risk factors in CVD and cancer
Increased cancer incidence and worse cancer-specific outcomes in patients with prevalent CVD
Increased risk of recurrence and cancer-specific mortality in patients with incident (post-cancer diagnosis) CVD
Mechanisms of CVD-induced cancer pathogenesis in preclinical models
Future directions and clinical implications
Funding
References
ABSTRACT
The field of cardio-oncology has emerged in response to the increased risk of cardiovascular disease (CVD) in patients with cancer. However, recent studies suggest a more complicated CVD-cancer relationship, wherein development of CVD, either prior to or following a cancer diagnosis, can also lead to increased risk of cancer and worse outcomes for patients. In this review, we describe the current evidence base, across epidemiological as well as preclinical studies, which supports the emerging concept of ‘reverse-cardio oncology’, or CVD-induced acceleration of cancer pathogenesis.
Introduction
The field of cardio-oncology has evolved from observations of increased risk of cardiovascular disease (CVD) following a cancer diagnosis [1]. The increased CVD risk is linked to both direct (e.g. cardiotoxic) and indirect (e.g. sedentary lifestyle) complications of cancer treatments [2], and the cardio-oncology field continues to grow with the introduction of new immunotherapies, with various cardiotoxic sequelae, and expansion of their clinical use [3].