گزارشی در مورد درمان ضد رتروویروسی در بیمار مبتلا به HIV-1
ترجمه نشده

گزارشی در مورد درمان ضد رتروویروسی در بیمار مبتلا به HIV-1

عنوان فارسی مقاله: پاسخ تاخیردار درمان ضد رتروویروسی در بیمار مبتلا به HIV-1 به دلیل عفونت های هپاتیت B و C: اولین گزارش موردی در نپال
عنوان انگلیسی مقاله: Late Response of Antiretroviral Therapy in an HIV-1-Infected Patient due to Hepatitis B and C Coinfections: The First Case Report in Nepal
مجله/کنفرانس: گزارش موارد در پزشکی - Case Reports in Medicine
رشته های تحصیلی مرتبط: پزشکی
گرایش های تحصیلی مرتبط: ایمنی شناسی پزشکی، آسیب شناسی پزشکی، ویروس شناسی پزشکی، خون و انکولوژی
شناسه دیجیتال (DOI): https://doi.org/10.1155/2019/2070973
دانشگاه: HIV Reference Unit, National Public Health Laboratory (NPHL), Teku, Kathmandu, Nepal
صفحات مقاله انگلیسی: 7
ناشر: هینداوی - Hindawi
نوع ارائه مقاله: ژورنال
نوع مقاله: ISI
سال انتشار مقاله: 2019
فرمت مقاله انگلیسی: PDF
وضعیت ترجمه: ترجمه نشده است
قیمت مقاله انگلیسی: رایگان
آیا این مقاله بیس است: خیر
آیا این مقاله مدل مفهومی دارد: ندارد
آیا این مقاله پرسشنامه دارد: ندارد
آیا این مقاله متغیر دارد: ندارد
کد محصول: E12934
رفرنس: دارای رفرنس در داخل متن و انتهای مقاله
فهرست مطالب (انگلیسی)

1- Introduction

2- Case Presentation

3- Discussion

4- Conclusions

References

بخشی از مقاله (انگلیسی)

Introduction

Hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV) are common viral infections that share routes of transmission through unprotected sex and exchanging needles/syringes. HBV and HCV coinfections are widespread among HIV-infected patients worldwide, which cause long-term illness to chronic hepatitis and death. Viral hepatitis progresses faster in HIV-infected patients compared to those without HIV. Although the antiretroviral therapy (ART) extended the life expectancy of people with HIV, viral hepatitis associated with HBV and HCV becomes the primary cause of morbidity and mortality. As documented, 36.7 million people are living with HIV/AIDS, and 1 million died of HIV-related illness worldwide in 2016. Among them, 3.5 million people are covered by Southeast Asia [1]. In Nepal, 30,646 people are HIV positive, and common risk groups were client of sex workers (34.1%), IDU (10.5%), migrant workers (9.3%), spouse migrants (6.3%), sex workers (4.9%), men having sex with men (1.8%), blood/blood products (0.4%), and others (32.8%) [2]. *e estimated global prevalence of people living with chronic HBV and HCV infection was 240 and 184 million, respectively [3, 4]. *e burden and clinical severity of HBV/HCV coinfection in HIV-infected people are rare but require continued follow-up with frequent testing of serum markers as well as molecular detection and quantification of viral nucleic acids with careful observation. *e molecular testing of HBV and HCV coinfections in a key population of HIV patients is convincing to estimate the true prevalence that provides accurate and justifiable data. However, the data of HBV/HCV coinfection in Nepalese population are infrequently recognized, uneven quality, uncategorized, scattered, and rarely reported. In this case report, we present a rare case of HBV and HCV coinfections in an HIV-1-infected patient with an improved CD4+ count but detectable viral loads after ART. Such triple coinfections in the patient from developing countries like Nepal provide an opportunity to access the effects of viral hepatitis coinfection on immediate and longstanding outcomes after antiretroviral therapy. Also, coinfection could be an exciting model for viral interaction studies and their clearance in response to immune cells.