بیماری صرع و درمان جدید برای آن
ترجمه نشده

بیماری صرع و درمان جدید برای آن

عنوان فارسی مقاله: درمان جدید برای بیماری صرع در دست اقدام
عنوان انگلیسی مقاله: Novel therapies for epilepsy in the pipeline
مجله/کنفرانس: صرع و رفتار - Epilepsy & Behavior
رشته های تحصیلی مرتبط: پزشکی
گرایش های تحصیلی مرتبط: مغز و اعصاب، ژنتیک پزشکی
کلمات کلیدی فارسی: صرع، تشنج، مقاومت به دارو، درمان
کلمات کلیدی انگلیسی: Epilepsy، Seizure، Drug resistance، Treatment
نوع نگارش مقاله: مقاله مروری (Review Article)
نمایه: Scopus - Master Journals List - MedLine - JCR
شناسه دیجیتال (DOI): https://doi.org/10.1016/j.yebeh.2019.04.042
دانشگاه: Hamad Medical Corporation and Weill Cornell Medical College-Qatar, Doha, Qatar
صفحات مقاله انگلیسی: 9
ناشر: الزویر - Elsevier
نوع ارائه مقاله: ژورنال
نوع مقاله: ISI
سال انتشار مقاله: 2019
ایمپکت فاکتور: 2/535 در سال 2018
شاخص H_index: 91 در سال 2019
شاخص SJR: 1/299 در سال 2018
شناسه ISSN: 1525-5050
شاخص Quartile (چارک): Q1 در سال 2018
فرمت مقاله انگلیسی: PDF
وضعیت ترجمه: ترجمه نشده است
قیمت مقاله انگلیسی: رایگان
آیا این مقاله بیس است: خیر
آیا این مقاله مدل مفهومی دارد: ندارد
آیا این مقاله پرسشنامه دارد: ندارد
آیا این مقاله متغیر دارد: ندارد
کد محصول: E12975
رفرنس: دارای رفرنس در داخل متن و انتهای مقاله
فهرست مطالب (انگلیسی)

Abstract

1- Introduction

2- P-glycoprotein inhibitors

3- Gene therapy

4- Stem cell therapy

5- Traditional and novel antiepileptic devices

6- Precision medicine

7- Advances in the therapy of epileptic encephalopathies in children

References

بخشی از مقاله (انگلیسی)

Abstract

Despite the availability of many antiepileptic drugs (AEDs) (old and newly developed) and, as recently suggested, their optimization in the treatment of patients with uncontrolled seizures, more than 30% of patients with epilepsy continue to experience seizures and have drug-resistant epilepsy; the management of these patients represents a real challenge for epileptologists and researchers. Resective surgery with the best rates of seizure control is not an option for all of them; therefore, research and discovery of new methods of treating resistant epilepsy are of extreme importance. In this article, we will discuss some innovative approaches, such as P-glycoprotein (P-gp) inhibitors, gene therapy, stem cell therapy, traditional and novel antiepileptic devices, precision medicine, as well as therapeutic advances in epileptic encephalopathy in children; these treatment modalities open up new horizons for the treatment of patients with drug-resistant epilepsy.

Introduction

For decades, the epilepsy community has addressed the burden of drug-resistant epilepsy by focusing on the development of new antiepileptic drugs (AEDs) and advancing epilepsy surgery techniques. These approaches have resulted in some success, but the percentage of patients with drug-resistant epilepsy has not changed substantially. More than 30% of individuals with epilepsy have persistent seizures despite the use of appropriate therapies, i.e., they have drug-resistant epilepsy [1–3]. Therefore, investigating and discovering new ways and strategies to treat epilepsy is of paramount significance. There are multiple approaches in the pipeline to treat drug-resistant epilepsy. In this article, we are going to discuss some of the interesting and innovative approaches, which are potentially opening new horizons in treating patients with drug-resistant epilepsy. We have to mention that many of these plausible strategies need to be validated and should be tested in large double-blind randomized clinical trials.