یک آزمایش تصادفی کنترل شده در مورد تشدید بیماری مزمن انسداد ریوی
1- Introduction
2- Materials and Methods
3- Results
4- Discussion
5- Conclusion
References
Introduction
Globally, chronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity and mortality due to chronic disease. Te social and economic burden imposed by COPD is increasing in part due to the ageing population. Based on studies conducted at global obstructive pulmonary disease institutions, it is estimated that, by 2020, COPD will be the third leading cause of death in the world and the ffh largest source of global economic burden due to disease [1]. COPD is a common, preventable, and treatable disease. In addition to smoking, airway or alveolar abnormalities can be caused by the exposure of individuals to toxic particles or gases, resulting in persistent respiratory symptoms and airfow obstruction [2]. Te criteria for the diagnosis of COPD include patients with progressively worsening dyspnoea, persistent dyspnoea, aggravation of dyspnoea afer activity, or repeated chronic cough and expectoration production and/or a history of exposure to risk factors, and pulmonary function test results showing that afer the use of bronchodilators patients still have forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) <0.7, confrming the existence of persistent airfow limitation [2].
Conclusion
The use of safower yellow in the treatment of patients with AECOPD signifcantly shortened the average hospital stay of patients, reduced the average cost of hospitalization, shortened the mechanical ventilation time, reduced treatment cost and the consumption of medical resources, and achieved a certain cost-efectiveness ratio. Te research results obtained in this study provide a potential new strategy for treating AECOPD patients in poverty-stricken regions of developing countries more efectively. Based on these results, we plan to conduct a multicentre, large-sample, three-blind, double-dummy, completely randomized controlled clinical trial with increased sample size to explore the clinical efects of safower yellow on the treatment of AECOPD. We will also utilize molecular biology techniques to conduct indepth explorations of the molecular mechanisms, targets, and pathophysiological changes involved in drug therapy.