تأثیر لقاح مصنوعی در آندومتریوز
ترجمه نشده

تأثیر لقاح مصنوعی در آندومتریوز

عنوان فارسی مقاله: تأثیر IVF در آندومتریوز تهاجمی عمیق
عنوان انگلیسی مقاله: The impact of IVF on deep invasive endometriosis
مجله/کنفرانس: مجله اروپایی پزشکی زنان و زایمان و زیست شناسی تولید مثل. ایکس - European Journal of Obstetrics & Gynecology and Reproductive Biology: X
رشته های تحصیلی مرتبط: پزشکی
گرایش های تحصیلی مرتبط: جراحی زنان و زایمان، پزشکی داخلی، بیولوژی تولید مثل
کلمات کلیدی فارسی: آندومتروز عمیق تهاجمی، لقاح مصنوعی، عود
کلمات کلیدی انگلیسی: Deep invasive endometriosis، IVF، Recurrence
نوع نگارش مقاله: مقاله پژوهشی (Research Article)
نمایه: Scopus
شناسه دیجیتال (DOI): https://doi.org/10.1016/j.eurox.2019.100073
دانشگاه: Fondazione Ca’ Granda, Ospedale Maggiore Policlinico, Milan, Italy
ناشر: الزویر - Elsevier
نوع ارائه مقاله: ژورنال
نوع مقاله: ISI
سال انتشار مقاله: 2019
شناسه ISSN: 2590-1613
فرمت مقاله انگلیسی: PDF
تعداد صفحات مقاله انگلیسی: 5
وضعیت ترجمه: ترجمه نشده است
قیمت مقاله انگلیسی: رایگان
آیا این مقاله بیس است: خیر
آیا این مقاله مدل مفهومی دارد: ندارد
آیا این مقاله پرسشنامه دارد: ندارد
آیا این مقاله متغیر دارد: ندارد
کد محصول: E13001
رفرنس: دارای رفرنس در داخل متن و انتهای مقاله
فهرست انگلیسی مطالب

Abstract


Introduction


Materials and methods


Results


Comment


References

نمونه متن انگلیسی مقاله

Abstract


Objective Ovarian hyper-stimulation during IVF is associated with a significant raise in serum estrogens and one may expect detrimental effects on estrogen-dependent diseases such as endometriosis. However, available evidence from large case series of affected women performing IVF is generally reassuring with the possible exception of women carrying deep invasive lesions. On this basis we deemed important investigating more in depth whether women with deep invasive endometriosis could be a subgroup at higher risk of recurrence or disease progression during IVF. Study design Women with endometriosis who underwent IVF and who had a second evaluation after 3–6 months from a failed cycle were retrospectively reviewed. The main inclusion criteria were the presence of deep invasive endometriosis and/or a history of surgery for this form of the disease. The primary aim of the study was to determine the frequency of endometriosis-related complications in the interval between the two evaluations. Secondary aims were pain symptoms and lesion size modifications.


Results Eighty-four women were ultimately selected: baseline ultrasound documented deep invasive lesions in 60 of them. One case of possible endometriosis-related complication was recorded, corresponding to a rate of 1.2% (95%: 0.05%–5.5%) for the whole cohort and 1.7% (95%CI: 0.08–7.6%) for the subgroup of women with ultrasound detected lesions. This rate appears similar to the reported frequency of endometriosis progression in women not receiving IVF. No significant modifications in pain symptoms or lesions size occurred.


Conclusions Women with deep invasive endometriosis who underwent IVF do not seem to be exposed to a substantially increased risk of recurrence/disease progression. Larger evidence from independent groups is however required for a definitive conclusion.


Introduction


In vitro fertilization (IVF) is a possible option for the treatment of infertile women with endometriosis [1,2]. However, IVF not only exposes women to the well-known general risks of the procedure but, also, to some specific endometriosis-related risks [3]. Of relevance here is the hazard of disease-progression during the procedure. Indeed, endometriosis is an estrogen-dependent disease and peripheral levels of estrogens increase up to 10-folds during ovarian hyper-stimulation. Given this premise, some harmful effects on the natural history of the disease could be expected. However, the available evidence does not generally support this concern [4]. Several independent large case series failed to highlight major detrimental effects [5–10]. On the other hand, these reassuring data contrast with some case reports of severe complications [11–15]. The main characteristics of these cases are summarized in Table 1. Noteworthy, deep invasive peritoneal lesions (ie nodules infiltrating the peritoneum by >5 mm) [16] were highly common in these published cases, being present in at least 9 out of 13 affected women. On these bases, we hypothesized that women with deep invasive endometriosis may be a subgroup of women who are more vulnerable to the potential detrimental effects of ovarian hyper-stimulation. To the best of our knowledge, only one study specifically reported evidence on deep lesions and failed to show detrimental effects. However, the evaluation of the lesions was a secondary finding, the number of included cases was extremely limited (n = 9) and the study did not focus on clinical complications [8]. Given the clinical relevance of the described cases, we deemed important exploring more in-depth this issue.

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