تاثیر بیماری کبد چرب غیر الکلی در تشدید التهاب لوزالمعده
1- Introduction
2- Methods
3- Results
4- Discussion
5- Conclusions
References
Introduction
Acute pancreatitis (AP) is an infammatory disease of the pancreas, with 10–20% of patients progressing to multiple organ failure coupled with a high mortality rate. Te incidence of AP is increasing year by year, consistent with an increase in the number of people with metabolic syndrome. Te incidence of local and systemic complications, especially mortality in patients with AP with metabolic syndrome, is noteworthy [1]. Metabolic syndrome is a clinical diagnosis based on the identifcation of related metabolic status. It can increase the risk of cardiovascular diseases, including diabetes, dyslipidemia, arterial hypertension, and abdominal obesity [2]. Abdominal obesity, a typical phenotype of metabolic syndrome, has been demonstrated to be an independent risk factor for AP [3]. Many clinical studies have confrmed that abdominal obesity can increase the severity of AP, prolong hospital stay, and increase the intensive care unit occupancy rate and mortality [4, 5]. Nonalcoholic fatty liver disease (NAFLD) is a phenotype of metabolic syndrome in the liver. NAFLD is related to all the components of metabolic syndrome and may be considered an additional component of the disease itself [6].
Conclusions
In summary, our results demonstrated that the presence of NAFLD at admission portends a higher risk of moderately severe and SAP, as well as a higher risk of SIRS and organ failure. In the clinical environment, we should pay close attention to the phenomenon of NAFLD aggravation of the severity of AP.