بزرگ شدن آمیگدال در صرع لوب موقت
ترجمه نشده

بزرگ شدن آمیگدال در صرع لوب موقت

عنوان فارسی مقاله: ضایعه طولانی مدت بزرگ شدن آمیگدال در صرع لوب موقت
عنوان انگلیسی مقاله: Long term sequelae of amygdala enlargement in temporal lobe epilepsy
مجله/کنفرانس: تشنج – seizures
رشته های تحصیلی مرتبط: پزشکی
گرایش های تحصیلی مرتبط: مغز و اعصاب
کلمات کلیدی فارسی: آمیگدال، بزرگ شدن، صرع لوب موقت
کلمات کلیدی انگلیسی: Amygdala، Enlargement، Temporal lobe epilepsy
نوع نگارش مقاله: مقاله پژوهشی (Research Article)
نمایه: Scopus – Master Journals List – JCR
شناسه دیجیتال (DOI): https://doi.org/10.1016/j.seizure.2019.11.015
دانشگاه: Calgary Comprehensive Epilepsy Program, Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, AB, Canada
ناشر: الزویر - Elsevier
نوع ارائه مقاله: ژورنال
نوع مقاله: ISI
سال انتشار مقاله: 2020
ایمپکت فاکتور: 2.856 در سال 2018
شاخص H_index: 76 در سال 2019
شاخص SJR: 1.172 در سال 2018
شناسه ISSN: 1059-1311
شاخص Quartile (چارک): Q2 در سال 2018
فرمت مقاله انگلیسی: PDF
تعداد صفحات مقاله انگلیسی: 8
وضعیت ترجمه: ترجمه نشده است
قیمت مقاله انگلیسی: رایگان
آیا این مقاله بیس است: خیر
آیا این مقاله مدل مفهومی دارد: ندارد
آیا این مقاله پرسشنامه دارد: ندارد
آیا این مقاله متغیر دارد: ندارد
کد محصول: E14126
رفرنس: دارای رفرنس در داخل متن و انتهای مقاله
فهرست انگلیسی مطالب

Abstract


Abbreviations


۱٫ Introduction


۲٫ Methods


۳٫ Results


۴٫ Discussion


Funding


Declaration of Competing Interest


References

نمونه متن انگلیسی مقاله

Abstract


Purpose: Amygdala enlargement (AE) has been reported in drug resistant lesional and non-lesional temporal lobe epilepsy (TLE). Its contribution to development of intractability of epilepsy is at best uncertain. Our aim was to study the natural course of AE in a heterogenous group of TLE patients with follow-up imaging and clinical outcomes. Methods: A prospective observational study in patients with TLE with imaging features of AE recruited from epilepsy clinics between 1994 and 2018. Demographic data, details of epilepsy syndrome, outcomes and follow up neuroimaging were extracted. Results: Forty-two patients were recruited including 19 males (45 %). Mean age at onset of epilepsy was 30.6 years and mean duration of epilepsy was 19.9 years. On MRI, 33 patients had isolated unilateral AE and eleven had AE with hippocampal enlargement (HE). Twenty (48 %) underwent temporal resections with most common histopathology being amygdalar gliosis (40 %). Engel Class IA outcome at last follow up (mean, 10 years) was 60 %. Thirty-four patients had neuroimaging follow up of at least 1 year (mean, 5 years). AE resolved in 6, persisted in 25, evolved into bilateral HS in 1, bilateral mesial temporal atrophy in 1 and ipsilateral mesial temporal atrophy in 1. Resolution of AE was associated with better seizure free outcomes (p = 0.013). Conclusions: TLE with AE is associated with favourable prognosis yet not benign. Over 50 % were drug resistant and surgical outcomes were similar to mTLE. Resolution of AE on follow up neuroimaging was associated with better seizure free outcomes.


Introduction


Mesial temporal lobe epilepsy (mTLE) is major contributor to the group of drug resistant epilepsies and is one of the leading indications for epilepsy surgery, the most common pathology being hippocampal sclerosis (HS) [1]. There is a significant group of patients with mTLE that do not have any lesions on MRI, called “non-lesional” or “MRInegative [2]. These patients pose a challenge for treatment in terms of difficult presurgical work-up, frequently warranting intracranial EEG recordings. There is evidence that non-lesional patients fare worse in surgical outcomes in general as compared to lesional ones [3]. Interestingly, there is accumulating evidence that MRI-negative epilepsies are not necessarily non-lesional [4]. The amygdala, which is part of the limbic system, is known to be part of the epileptogenic network of patients with mTLE [5]. Intracranial EEG recordings have revealed interictal epileptiform discharges (IEDs) arising from the amygdala [6]. Structural abnormalities of the amygdala may be difficult to detect by conventional MR techniques [7], and thus may contribute to the so called non-lesional temporal lobe epilepsy (TLE-NL). Imaging studies of TLE-NL patients have identified amygdala enlargement (AE) as an increase in grey matter and amygdalar volume in 12 % of patients [8]. The same authors reported similar proportion (14 %) of AE in patients with mTLE and HS [9]. While the role of the amygdala is functionally defined and evidence of epileptogenicity in the amygdala exists, the significance of AE remains undefined.

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