نفوذ پذیری پلی ساکارید سولفات از کاهوی دریایی
ترجمه نشده

نفوذ پذیری پلی ساکارید سولفات از کاهوی دریایی

عنوان فارسی مقاله: اثر پذیری پلی ساکارید های سولفات از کاهوی دریایی دارای فاکتورهای لختگی Xa و IIa و تشکیل لخته خون سیاهرگی
عنوان انگلیسی مقاله: Influence of sulfated polysaccharides from Ulva lactuca L. upon Xa and IIa coagulation factors and on venous blood clot formation
مجله/کنفرانس: تحقیقات جلبکی – Algal Research
رشته های تحصیلی مرتبط: زیست شناسی، پزشکی
گرایش های تحصیلی مرتبط: علوم سلولی و مولکولی، هماتولوژی
کلمات کلیدی فارسی: کاهوی دریایی،پلی ساکاریدهای سولفات، فعالیت های ضد انعقاد و لختگی
کلمات کلیدی انگلیسی: Ulva lactuca L, Sulfated polysaccharides, Anticoagulant and antithrombotic activity
نوع نگارش مقاله: مقاله پژوهشی (Research Article)
نمایه: Scopus – Master Journals List – JCR
شناسه دیجیتال (DOI): https://doi.org/10.1016/j.algal.2019.101750
دانشگاه: Universidade Federal de Juiz de Fora, Brazil
ناشر: الزویر - Elsevier
نوع ارائه مقاله: ژورنال
نوع مقاله: ISI
سال انتشار مقاله: 2020
ایمپکت فاکتور: 3.977 در سال 2019
شاخص H_index: 44 در سال 2020
شاخص SJR: 1.193 در سال 2019
شناسه ISSN: 2211-9264
شاخص Quartile (چارک): Q1 در سال 2019
فرمت مقاله انگلیسی: PDF
تعداد صفحات مقاله انگلیسی: 8
وضعیت ترجمه: ترجمه نشده است
قیمت مقاله انگلیسی: رایگان
آیا این مقاله بیس است: خیر
آیا این مقاله مدل مفهومی دارد: ندارد
آیا این مقاله پرسشنامه دارد: ندارد
آیا این مقاله متغیر دارد: ندارد
کد محصول: E14167
رفرنس: دارای رفرنس در داخل متن و انتهای مقاله
فهرست انگلیسی مطالب

Abstract


Graphical abstract


1- Introduction


2- Materials and methods


3- Results and discussion


4- Conclusions


Acknowledgments


References

نمونه متن انگلیسی مقاله

Abstract


The interest in bioactive compounds from natural sources, such as marine organisms, has increased considerably in recent years. Among these compounds, sulfated polysaccharides from seaweed exhibit a broad spectrum of biological activities. Sulfated polysaccharides from green algae are still poorly investigated. For this reason, in this study, using unusual methodologies, such as extraction conditions, FACE, and RAMAN, we investigated the structural features of F50UL and F70UL sulfated polysaccharides from Ulva lactuca L. and their distinct in vitro anticoagulant and in vivo antithrombotic activities. Sulfated polysaccharides of U. lactuca were obtained by enzymatic proteolysis with ALCALASE® and fractionated by acetone precipitation. F50Ul and F70Ul sulfated polysaccharides with higher yield were partially chemically characterized by Fluorophore-assisted carbohydrate electrophoresis (FACE) and RAMAN spectroscopy analysis and submitted to an in vitro screening by APTT, PT, TT, and anti-factor Xa and IIa tests. The venae cavae ligature experimental model for the analysis of in vivo antithrombotic activity of F50Ul and F70Ul sulfated polysaccharides were also performed. The U. lactuca L. sulfated polysaccharides characterization by FACE and RAMAN showed a typical ulvans structure that contains as principal component rhamnose, but other monosaccharides (uronic acid, glucose, and galactose) are present. F50Ul (0.1–۱٫۰ μg/μl) showed anticoagulant activity in vitro. However, F70Ul that has a similar composition did not present these effects. Also, only F50Ul sulfated polysaccharides (≥۵ μg/g) showed a great in vivo antithrombotic concentration-dependent and time-dependent activity. In summary, we demonstrate the use of unusual extraction and characterization analysis procedures for U. lactuca L. sulfated polysaccharides and the ability of F50Ul to reduce the weight of thrombus in rats probably by the association with factors Xa and IIa inhibition. These results provide strong evidence of the anticoagulant potential of these sulfated polysaccharides isolated from Ulva lactuca L.


Introduction


According to the World Health Organization, cardiovascular diseases are the major cause of death worldwide. An approximate calculation has shown that over 23.6 million people will die due to cardiovascular diseases until 2030. It is associated with heart and blood vessels disorders and includes coronary heart disease, hypertension, stroke (cerebrovascular), rheumatic heart and peripheral vascular diseases [1]. Arterial thrombosis is one of the most common causes of death in the world due to either instability or rupture of an atherosclerotic plaque resulting in localized clot formation and blockage of blood flow with subsequent myocardial infarction (heart attack) or stroke [2].


The physiologic action of the hemostatic system removes fibrin deposits from vessels and maintains the circulating blood in a fluidic state. In cases of vessel injury, the tissue factor on adventitial cells, such as adventitial fibroblasts and smooth muscle cells activates the clotting system with a complex series of enzymatic reactions involving coagulation proteins, culminating in the activation of thrombin, which converts fibrinogen to fibrin. Thus, it forms a stable clot and prevents excessive blood loss. While hemostatic clots are localized to the vessel wall and do not impair blood flow, the thrombotic clots result in impairment of blood flow and even complete occlusion of the vessel [2]. In this case, anticoagulation therapy is required for inhibition of blood clotting using appropriate drugs, i.e., warfarin or heparin [3].

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