تخمین میزان بروز منطقه ای و جهانی در مورد سرطان در دوران کودکی
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تخمین میزان بروز منطقه ای و جهانی در مورد سرطان در دوران کودکی

عنوان فارسی مقاله: سرطان در دوران کودکی: تخمین میزان بروز منطقه ای و جهانی
عنوان انگلیسی مقاله: Childhood cancer: Estimating regional and global incidence
مجله/کنفرانس: اپیدمیولوژی سرطان - Cancer Epidemiology
رشته های تحصیلی مرتبط: پزشکی
گرایش های تحصیلی مرتبط: اپیدمیولوژی، ایمنی شناسی، آسیب شناسی
کلمات کلیدی فارسی: سرطان در دوران كودكی، شیوع مرض، برآوردها، جهاني، ثبت سرطان، سرطان لنفی، ساركوم كاپوسي، برآوردهای جهاني
کلمات کلیدی انگلیسی: Childhood cancer، Incidence، Estimates، Global، Cancer registry، Burkitt lymphoma، Kaposi sarcoma، Global estimates
نوع نگارش مقاله: مقاله پژوهشی (Research Article)
نمایه: MedLine - Scopus - Master Journals List - JCR
شناسه دیجیتال (DOI): https://doi.org/10.1016/j.canep.2019.101662
دانشگاه: Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, York, United Kingdom
ناشر: الزویر - Elsevier
نوع ارائه مقاله: ژورنال
نوع مقاله: ISI
سال انتشار مقاله: 2020
ایمپکت فاکتور: 2/679 در سال 2019
شاخص H_index: 68 در سال 2020
شاخص SJR: 1/327 در سال 2019
شناسه ISSN: 1877-7821
شاخص Quartile (چارک): Q1 در سال 2019
فرمت مقاله انگلیسی: PDF
تعداد صفحات مقاله انگلیسی: 12
وضعیت ترجمه: ترجمه نشده است
قیمت مقاله انگلیسی: رایگان
آیا این مقاله بیس است: خیر
آیا این مقاله مدل مفهومی دارد: ندارد
آیا این مقاله پرسشنامه دارد: ندارد
آیا این مقاله متغیر دارد: ندارد
کد محصول: E14333
رفرنس: دارای رفرنس در داخل متن و انتهای مقاله
فهرست انگلیسی مطالب

Abstract


1- Introduction


2- Methods


3- Results


4- Discussion


5- Conclusions


References

نمونه متن انگلیسی مقاله

Abstract


Background
Most of the world’s population is not covered by cancer surveillance systems or vital registration, and worldwide/UN-regional cancer incidence is estimated using a variety of methods. Quantifying the cancer burden in children (<15 years) is more challenging than in adults; childhood cancer is rare and often presents with non-specific symptoms that mimic those of more prevalent infectious and nutritional conditions.
Methods
A Baseline Model (BM) was constructed comprising a set of quality assured sex- and age-specific cancer rates derived from the US Surveillance, Epidemiology and End Results (SEER) program, for diagnostic groups of the International Classification of Childhood Cancers (ICCC-3) 3rd edition, and information on a known risk factor for endemic Burkitt lymphoma and Kaposi’s sarcoma. These rates were applied to global country-level population data for 2015 to estimate the global and regional incidence of childhood cancer. Results were compared to GLOBOCAN 2018, extrapolations from the International Incidence of Childhood Cancer (IICC-3) and estimates from the Global Childhood Cancer (GCC) model (based on IICC-3 data combined with information on health care systems and other parameters). Results
The BM estimated 360,114 total childhood cancers occurring worldwide in 2015; 54% in Asia and 28% in Africa. BM estimated standardised rates ranged from ∼178 cases per million in Europe and North America, through to ∼218 cases per million in West and Middle Africa. Totals from GLOBOCAN and extrapolations from the IICC-3 study were lower (44.6% and 34.7% respectively), but the estimate from the GCC model was 10.2% higher. In all models, agreement was good in countries with very high human development index (HDI), but more variable in countries with medium and low HDIs; the discrepancies correlating with registration coverage across these settings.
Conclusion
Disagreements between the BM estimates and other sources occur in areas where health systems are insufficiently equipped to provide adequate access to diagnosis, treatment, and supportive care. Incorporating aetiological evidence into the BM enabled the estimation of the additional burden of Burkitt lymphoma and Kaposi sarcoma; similar adjustments could be applied to other cancers, as and when information becomes available.


Conclusions


Using the original baseline model (BM) we estimated that approximately 360,000 cancers occurred in children in 2015 worldwide. These data were derived by imputing identical background incidence of childhood cancer to all world regions and correcting them for an effect of P. falciparum infection according to the known spread of this exposure. Our approach suggests that up to 45% of incident childhood cancers may be undocumented within existing (childhood) cancer surveillance systems. A majority of the children whose cancer diagnoses are missed reside in countries with lower human development index; indicating a need for improved provision, accessibility and utilisation of appropriate diagnostics and care and documentation of diagnosed cases.

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