یک مطالعه هم گروهی در مورد تسکین خودکشی اظهار شده در اسکیزوفرنی
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یک مطالعه هم گروهی در مورد تسکین خودکشی اظهار شده در اسکیزوفرنی

عنوان فارسی مقاله: تسکین خودکشی اظهار شده در اسکیزوفرنی پس از درمان با الکتروشوک: یک مطالعه هم گروهی موافق با اصول طبیعی
عنوان انگلیسی مقاله: Relief of expressed suicidality in schizophrenia after electroconvulsive therapy: A naturalistic cohort study
مجله/کنفرانس: تحقیقات روانپزشکی - Psychiatry Research
رشته های تحصیلی مرتبط: پزشکی، روانشناسی
گرایش های تحصیلی مرتبط: روانپزشکی، روانشناسی بالینی
کلمات کلیدی فارسی: الکتروشوک درمانی، اسکیزوفرنی، خودکشی
کلمات کلیدی انگلیسی: ECT، Schizophrenia، Suicide
نوع نگارش مقاله: مقاله پژوهشی (Research Article)
نمایه: Scopus - Master Journals List - JCR - MedLine
شناسه دیجیتال (DOI): https://doi.org/10.1016/j.psychres.2020.112759
دانشگاه: Department of Mood and Anxiety, Institute of Mental Health, , 10 Buangkok View, Buangkok Green Medical Park, Hougang 539747, Singapore
ناشر: الزویر - Elsevier
نوع ارائه مقاله: ژورنال
نوع مقاله: ISI
سال انتشار مقاله: 2020
ایمپکت فاکتور: 2/368 در سال 2019
شاخص H_index: 118 در سال 2020
شاخص SJR: 1/137 در سال 2019
شناسه ISSN: 0165-1781
شاخص Quartile (چارک): Q1 در سال 2019
فرمت مقاله انگلیسی: PDF
تعداد صفحات مقاله انگلیسی: 4
وضعیت ترجمه: ترجمه نشده است
قیمت مقاله انگلیسی: رایگان
آیا این مقاله بیس است: بله
آیا این مقاله مدل مفهومی دارد: ندارد
آیا این مقاله پرسشنامه دارد: ندارد
آیا این مقاله متغیر دارد: ندارد
کد محصول: E14436
رفرنس: دارای رفرنس در داخل متن و انتهای مقاله
فهرست انگلیسی مطالب

Abstract


1- Introduction


2- Methods


3- Results


4- Discussion


5- Conclusion


References

نمونه متن انگلیسی مقاله

Abstract


Suicide risk in schizophrenia is a significant treatment challenge but there are few approved treatments. Electroconvulsive therapy (ECT) is a highly effective treatment for suicidality in depression but its effect on suicidality in schizophrenia is unclear. We conducted a retrospective naturalistic study of the real-world effect of ECT on expressed suicidality as assessed by item 4 of the 24-item Brief Psychiatric Rating Scale in 113 patients with treatment resistant schizophrenia receiving ECT. 19.5% of patients expressed suicidal ideation pre-ECT of which 86.4% experienced an improvement in expressed suicidality after an average of 10.2 (SD 2.7) sessions of ECT. Changes in suicide scores before and after ECT was examined using a generalized estimating equation (GEE) model which showed that the effect of ECT on suicide was significantly mediated by depression and explained 72.2% of the decreased in expressed suicidality. ECT is effective in decreasing depression and expressed suicidality in patients with schizophrenia and should be considered as a treatment option for managing suicidality and psychosis in patients with treatment resistant schizophrenia.


Introduction


Schizophrenia is a chronic severe mental illness with premature mortality that is partially accounted for by increased suicides (Palmer et al., 2005). The lifetime risk of suicide in schizophrenia is estimated to be as high as 13% (Drake et al., 1985) and 8.5 fold that of the general population (Harris and Barraclough, 1997). Despite this high risk of suicide, there are few approved treatments to address suicidality in schizophrenia (Kasckow et al., 2011). Only clozapine is US FDA approved to treat suicidality in schizophrenia (Meltzer et al., 2003) and SSRIs may be helpful to decrease suicidality in schizophrenia (Zisook et al., 2010). Electroconvulsive therapy (ECT) is the oldest somatic treatment modality in psychiatry still in current use (Cerletti and Bini, 1938). It is the most effective acute treatment for severe depression (Carney et al., 2003) and also effective in reducing psychotic symptoms in treatment resistant schizophrenia (American Psychiatric Association, 2008; Petrides et al., 2014; Tharyan and Adams, 2005). ECT is highly effective in rapidly decreasing suicidality in depression (Fink et al., 2014; Kellner et al., 2005; Prudic and Sackeim, 1999) and can be life saving for some patients. However, the effect of ECT on suicidality in schizophrenia is unclear. We thus set out to investigate the effect of ECT on expressed suicidality in schizophrenia in a large naturalistic cohort of patients with treatment resistant schizophrenia receiving ECT. Singapore is a small nation state at the tip of the Malaysian archipelago. It has a population of approximately 5.5 million people consisting of 74.3% ethnic Chinese, 13.3% Malays and 9.1% Indian (Department of Statistics Singapore, 2016). The Singapore Institute of Mental Health (IMH) is the only tertiary psychiatric hospital in Singapore and has 1900 inpatient beds and about 40,000 outpatients. The IMH treats about 80% of the national load of patients with schizophrenia. At the IMH, ECT is prescribed primarily for schizophrenia (47%) with schizoaffective disorder (20.3%), depression (20.4%) and mania (6.8%) being the other major indications. ECT was effective in treating psychotic symptoms in 64.5% of patients with schizophrenia and also improved cognitive functioning in these patients (Tor et al., 2017).

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