آسیب شناسی بافت سرطان روده بزرگ
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آسیب شناسی بافت سرطان روده بزرگ

عنوان فارسی مقاله: آسیب شناسی بافت طیفی مجازی سرطان روده بزرگ – کاربردهای زیست پزشکی طیف سنجی و تصویربرداری رامان
عنوان انگلیسی مقاله: Virtual spectral histopathology of colon cancer – biomedical applications of Raman spectroscopy and imaging
مجله/کنفرانس: مجله مایعات مولکولی – Journal of Molecular Liquids
رشته های تحصیلی مرتبط: مهندسی پزشکی، پزشکی
گرایش های تحصیلی مرتبط: بیوالکتریک، پردازش تصاویر پزشکی، گوارش و کبد، آسیب شناسی پزشکی
کلمات کلیدی فارسی: سرطان روده بزرگ، طیف سنجی رامان، تصویربرداری رامان، نشانگرهای زیستی سرطان، تشخیص
کلمات کلیدی انگلیسی: Colon cancer, Raman spectroscopy, Raman imaging, cancer biomarkers, diagnostics
نوع نگارش مقاله: مقاله پژوهشی (Research Article)
نمایه: Scopus – Master Journals List – JCR
شناسه دیجیتال (DOI): https://doi.org/10.1016/j.molliq.2020.112676
دانشگاه: Laboratory of Laser Molecular Spectroscopy, Institute of Applied Radiation Chemistry, Lodz University of Technology, 93-590 Lodz, Poland
ناشر: الزویر - Elsevier
نوع ارائه مقاله: ژورنال
نوع مقاله: ISI
سال انتشار مقاله: 2020
ایمپکت فاکتور: 4.854 در سال 2019
شاخص H_index: 82 در سال 2020
شاخص SJR: 0.862 در سال 2019
شناسه ISSN: 0167-7322
شاخص Quartile (چارک): Q1 در سال 2019
فرمت مقاله انگلیسی: PDF
تعداد صفحات مقاله انگلیسی: 22
وضعیت ترجمه: ترجمه نشده است
قیمت مقاله انگلیسی: رایگان
آیا این مقاله بیس است: خیر
آیا این مقاله مدل مفهومی دارد: ندارد
آیا این مقاله پرسشنامه دارد: ندارد
آیا این مقاله متغیر دارد: ندارد
کد محصول: E14526
رفرنس: دارای رفرنس در داخل متن و انتهای مقاله
فهرست انگلیسی مطالب

Abstract


۱٫ Introduction


۲٫ Experimental


۳٫ Results and discussion


۴٫ Conclusion


Author statement


Abbreviations


Funding


Ethics approval and consent to participate


Declaration of competing interest


References

نمونه متن انگلیسی مقاله

Abstract


Colon cancer is one of the most commonly detected pathology and is the third worldwide cause of death in the US and Europe and ranks second with regard to the incidence of malignant tumors in population. Raman spectroscopy and imaging can be used for colon cancer detection and bioanalytical characterization of noncancerous and pathologically changed tissues. These studies included Raman spectroscopy measurement of not fixed and not stained tissues samples. Presented study included patients from Poland, who were ≥۱۸ years of age and underwent colon cancer surgery. Outcomes were measured using confocal Raman microscope, spectroscopy results were compared with traditional histopathology analysis outcomes. DNA, lipids, proteins and carotenoids can be treated as biomarkers of cancerogenesis. Ratios: 751/1156 (DNA/Carotenoids), 1228/1332 (β -sheet/α -helix proteins conformation), 1586/1004 (Phosphorylated proteins/Proteins), 2854/2935 (Lipids/Proteins) can be used to differentiate noncancerous and cancerous human sigmoid colon mucosa based on Raman spectroscopy and imaging. We have proved that Raman spectroscopy and imaging are a powerful technique to distinguish between noncancerous and cancerous human sigmoid colon mucosa and to characterize biochemical composition of multilayer sigmoid colon tissues samples.


Introduction


Nowadays Raman spectroscopy and imaging have been recognized as a powerful tool in bioanalytical, biochemical and medical applications. High sensitivity and specificity, above 90%, especially related to the fingerprint region of Raman spectr a , offer precise identification of biomarkers based on their unique vibrations. The great advantage of Raman spectroscopy and imaging is also related to the fact that samples analysis doesn’t require any staining, which is beneficial in terms of time -consuming protocols and analysis costs . As a consequence , Raman based methods including Raman spectroscopy and imaging have emerged in last years as one of the most important alternative s for traditional ex vivo human tissue examination by H&E staining and highly efficient tool for biomedical applications [ 1 – 11]. A considerable progress in the field of in vivo – clinical assessment, especially due to the spectroscopic fiber technologies is also observed [12, 13]. Colon cancer , one of the most commonly detected pathology is the third worldwide cause of death with mortality around 60% in the United States and Europe and ranks second with regard to the incidence of malignant tumors in population [14]. The main endoscopic examination used in clinical practice for colon cancer screening is colonoscopy. However, colonoscopy has some disadvantages and risk such as colonic perforation occurring in approximately 1 in 1000 cases, or hemorrhagic complications that may occur during or after colonoscopy. When combined with anesthesia, other difficulties may include cardiovascular complications such as a temporary drop in blood pressure, the risk of blood clots, pulmonary embolism or deep vein thrombosis.

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