درک هم شنوی میان میزبان و ویروس در ماکیان
ترجمه نشده

درک هم شنوی میان میزبان و ویروس در ماکیان

عنوان فارسی مقاله: درک هم شنوی میان میزبان و ویروس در ماکیان از دیدگاه میکروارنا
عنوان انگلیسی مقاله: Understanding the cross-talk between host and virus in poultry from the perspectives of microRNA
مجله/کنفرانس: علوم ماکیان – Poultry Science
رشته های تحصیلی مرتبط: دامپزشکی، پزشکی
گرایش های تحصیلی مرتبط: آسیب شناسی دامپزشکی، ویروس شناس پزشکی
کلمات کلیدی فارسی: هم شنوی، ماکیان، میکروارنا، عفونت ویروسی، ویروس – میزبان
کلمات کلیدی انگلیسی: cross-talk, poultry animal, microRNA, viral infection, virus-host
نوع نگارش مقاله: مقاله مروری (Review Article)
نمایه: Scopus – Master Journals List – JCR – MedLine
شناسه دیجیتال (DOI): https://doi.org/10.1016/j.psj.2019.11.053
دانشگاه:  Medical College of Soochow University, China
ناشر: الزویر - Elsevier
نوع ارائه مقاله: ژورنال
نوع مقاله: ISI
سال انتشار مقاله: 2020
ایمپکت فاکتور: 1.992 در سال 2019
شاخص H_index: 119 در سال 2020
شاخص SJR: 0.977 در سال 2019
شناسه ISSN: 0032-5791
شاخص Quartile (چارک): Q1 در سال 2019
فرمت مقاله انگلیسی: PDF
تعداد صفحات مقاله انگلیسی: 9
وضعیت ترجمه: ترجمه نشده است
قیمت مقاله انگلیسی: رایگان
آیا این مقاله بیس است: خیر
آیا این مقاله مدل مفهومی دارد: ندارد
آیا این مقاله پرسشنامه دارد: ندارد
آیا این مقاله متغیر دارد: ندارد
کد محصول: E14587
رفرنس: دارای رفرنس در داخل متن و انتهای مقاله
فهرست مطالب (انگلیسی)

Abstract


Introduction


Marek’s disease virus


Avian leukosis virus subgroup J


Influenza A virus


Other viruses Pathways significantly enriched by the targets of dysregulated miRNAs during viral infection


Conclusions


Acknowledgments


References

بخشی از مقاله (انگلیسی)

Abstract


In poultry, viral infections (e.g., Marek’s disease virus, avian leukosis virus, influenza A virus, and so on) can cause devastating mortality and economic losses. Because viruses are solely dependent on host cells to propagate, they alter the host intracellular microenvironment. Thus, understanding the virus-host interaction is important for antiviral immunity and drug development in the poultry industry. MicroRNAs are crucial posttranscriptional regulators of gene expression in a wide spectrum of biological processes, including viral infection. Recently, microRNAs have been identified as key players in virus-host interactions. In this review, we will discuss the intricacies involved in the virus-host cross-talk mediated by host and viral microRNAs in poultry (i.e., chicken and ducks), as well as recent trends and challenges in this field. These findings may provide some insights into the rapidly developing area of research regarding viral pathogenesis and antiviral immunity in poultry production. Introduction Many types of viruses will cause high mortality rates and enormous economic losses to the poultry industry. For example, Marek’s disease virus (MDV) and avian leukosis virus can induce neoplastic diseases in chickens. Moreover, influenza A virus (IAV) is highly variable and can spread across species, thereby resulting in a threat to global public health. Therefore, the cross-talk between the host (i.e., chickens) and viruses during infections is critical to understanding viral pathogenesis and antiviral immunity in chicken production. Over the past decade, studies have attempted to depict the cross-talk between the host and virus from different aspects (e.g., microRNA [miRNAs] perspective) and have made progress in this area (Li et al., 2014a; Skalsky and Cullen, 2010).


Introduction


miRNAs Are short noncoding 18- to 25-nucleotidelong RNAs that regulate gene expression at the posttranscriptional level. Substantial evidence demonstrates that a single miRNA can have extensive and crucial effects on a range of fundamental biological processes, and miRNA dysregulation can result in biological dysfunction and diseases (Bartel, 2004; Ha and Kim, 2014). Pathogen-induced phenotypic changes in hosts are always accompanied by remarkable alterations at the transcriptional level (Jenner and Young, 2005). The miRNA expression profile is profoundly influenced by viral infection and contributes to the repertoire of virus-host interactions. Differential miRNA expression can be attributed to both host antiviral defenses and alterations in cellular environment that are affected by viral factors (Scaria et al., 2007; Skalsky and Cullen, 2010; tenOever, 2013; Harwig et al., 2014; Powdrill et al., 2016; Nejad et al., 2018). Moreover, miRNAs have been reported to be biomarkers of viral infections (Wang et al., 2014) and have roles in viral reactivation from latency (Hicks et al., 2019). Therefore, the identification of deregulated miRNAs in virally infected chickens will provide novel insight into understanding virus-host interaction. In this review, we will summarize recent advances into the critical role of virally influenced poultry and viral miRNAs in the cross-talk between the host and virus to help understand viral pathogenesis and antiviral immunity in the poultry industry.

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