کاهش سمیت ترکیبات دارویی با استفاده از تنظیم مقاومت دارویی
ترجمه نشده

کاهش سمیت ترکیبات دارویی با استفاده از تنظیم مقاومت دارویی

عنوان فارسی مقاله: تنظیم مقاومت دارویی برای کاهش سمیت ترکیبات دارویی: گذشته، حال و آینده
عنوان انگلیسی مقاله: Monitoring of drug resistance towards reducing the toxicity of pharmaceutical compounds: Past, present and future
مجله/کنفرانس: مجله آنالیز زیست پزشکی و دارویی - Journal Of Pharmaceutical And Biomedical Analysis
رشته های تحصیلی مرتبط: پزشکی، داروسازی
گرایش های تحصیلی مرتبط: ایمنی شناسی، داروشناسی، سم شناسی، نانو فناوری پزشکی، پزشکی مولکولی
کلمات کلیدی فارسی: مقاومت دارویی، بیوآنالیز، نانومواد پیشرفته، سمیت، ترکیبات دارویی
کلمات کلیدی انگلیسی: Drug resistance، Bioanalysis، Advanced nanomaterials، Toxicity، Pharmaceutical compounds
نوع نگارش مقاله: مقاله مروری (Review Article)
شناسه دیجیتال (DOI): https://doi.org/10.1016/j.jpba.2020.113265
دانشگاه: Kidney Research center, Tabriz University of Medical Sciences, Tabriz, Iran
صفحات مقاله انگلیسی: 42
ناشر: الزویر - Elsevier
نوع ارائه مقاله: ژورنال
نوع مقاله: ISI
سال انتشار مقاله: 2020
ایمپکت فاکتور: 2/995 در سال 2019
شاخص H_index: 114 در سال 2020
شاخص SJR: 0/786 در سال 2019
شناسه ISSN: 0731-7085
شاخص Quartile (چارک): Q2 در سال 2019
فرمت مقاله انگلیسی: PDF
وضعیت ترجمه: ترجمه نشده است
قیمت مقاله انگلیسی: رایگان
آیا این مقاله بیس است: خیر
آیا این مقاله مدل مفهومی دارد: ندارد
آیا این مقاله پرسشنامه دارد: ندارد
آیا این مقاله متغیر دارد: ندارد
کد محصول: E14783
رفرنس: دارای رفرنس در داخل متن و انتهای مقاله
فهرست مطالب (انگلیسی)

Abstract

1- Introduction

2- Mechanisms and conventional methods towards monitoring of drug resistance

3- Electrochemical and Electrochemiluminescent (ECL) sensing

4- Electrical sensing

5- Optical sensing

6- The role of nanomaterials for the screening of drug resistance

7- Electrochemical nanosensor for the monitoring of drug resistance

8- Optical nanosensors for the monitoring of drug resistance

9- Electrochemiluminescence nanosensors for the monitoring of drug resistance

10- Photoelectrochemical (PEC) Nanosensors for the monitoring of drug resistance

11- Conclusion

References

بخشی از مقاله (انگلیسی)

Abstract

Drug resistance is worldwide health care crisis which decrease drug efficacy and developing toxicities. Effective resistance detection techniques could alleviate treatment cost and mortality associated with this crisis. In this review, the conventional and modern analysis methods for monitoring of drug resistance are presented. Also, various types of emerging rapid and sensitive techniques including electrochemical, electrical, optical and nano-based methods for the screening of drug resistance were discussed. Applications of various methods for the sensitive and rapid detection of drug resistance are investigated. The review outlines existing key issues in the determination which must be overcome before any of these techniques becomes a feasible method for the rapid detection of drug resistance. In this review, the roles of nanomaterials on development of novel methods for the monitoring of drug resistance were presented. Also, limitations and challenges of conventional and modern methods were discussed.

Introduction

Drug resistance as an emerging health concern reducing the efficiency and potency of a drug to produce effective treatment of pathogenic microorganisms or cancer and decrease overall patient survival [1]. During the cancer invasion and metastasis, large number of failures in the chemotherapy is related with the resistance of tumor cells to anticancer agents [2]. Consequently, resistance to drugs led to many other problems including toxicity and huge costs for development of new drugs [3]. In contemporary clinical practice, resistance to anticancer drugs can only be detected after long treatment periods [3]. Various mechanisms including reduced influx or enhanced efflux of drug, drug detoxification, glutathione conjugation, disrupt in DNA repair introduced for resistance against some anticancer agents like cisplatin [4]. It is important to point out that resistant to anticancer agents already exists before of chemotherapy in about half of cancer cases [3]. Thus, diagnostic tests for drug resistance in individual prior to commencing treatment with chemotherapy agents are required to predict the efficacy of chemotherapy and avoid any toxicity in normal tissues [3]. Several in vitro test analysis methods have been developed to assessment of resistance or sensitivity [5-7].