COVID-19 جهش یافته
ترجمه نشده

COVID-19 جهش یافته

عنوان فارسی مقاله: COVID-19 جهش یافته ممکن است پیش بینی از خطر بزرگی برای بشر در آینده باشد
عنوان انگلیسی مقاله: Mutated COVID-19 may foretell a great risk for mankind in the future
مجله/کنفرانس: میکروب ها و عفونت های جدید – New Microbes and New Infections
رشته های تحصیلی مرتبط: پزشکی
گرایش های تحصیلی مرتبط: ویروس شناس پزشکی، ژنتیک پزشکی، اپیدمیولوژی یا همه گیر شناسی، پزشکی مولکولی، بیماری های عفونی، ایمنی شناسی پزشکی یا ایمونولوژی
کلمات کلیدی فارسی: کووید ۱۹، سندرم تنفسی خاورمیانه، شیوع، سندرم حاد تنفسی، جانورشناسی
کلمات کلیدی انگلیسی: COVID-19, Middle-East respiratory syndrome, outbreaks, severe acute respiratory syndrome, zoonotic
نوع نگارش مقاله: مقاله مروری (Review Article)
شناسه دیجیتال (DOI): https://doi.org/10.1016/j.nmni.2020.100673
دانشگاه: College of Medicine, University of Mosul, Mosul, Iraq
صفحات مقاله انگلیسی: 8
ناشر: الزویر - Elsevier
نوع ارائه مقاله: ژورنال
نوع مقاله: ISI
سال انتشار مقاله: 2020
ایمپکت فاکتور: 1.602 در سال 2019
شاخص H_index: 17 در سال 2020
شاخص SJR: 0.780 در سال 2019
شناسه ISSN: 2052-2975
شاخص Quartile (چارک): Q3 در سال 2019
فرمت مقاله انگلیسی: PDF
وضعیت ترجمه: ترجمه نشده است
قیمت مقاله انگلیسی: رایگان
آیا این مقاله بیس است: خیر
آیا این مقاله مدل مفهومی دارد: ندارد
آیا این مقاله پرسشنامه دارد: ندارد
آیا این مقاله متغیر دارد: ندارد
کد محصول: E14855
رفرنس: دارای رفرنس در داخل متن و انتهای مقاله
فهرست مطالب (انگلیسی)

Abstract

Introduction

Prevalence and epidemiology

Virus structure

Clinical manifestation and symptoms

Preventions

Diagnosis

Treatment

Conclusions

Transparency declaration

Acknowledgement

References

بخشی از مقاله (انگلیسی)

Abstract

Coronavirus disease 2019 SARS-CoV-2 (COVID-19) is a zoonotic virus causing a variety of severe respiratory diseases. SARS-CoV-2 is closest to SARS-CoV and MERS-CoV in structure. The high prevalence of COVID-19 is a result of a lack of symptoms at onset. Our study aimed to present an overview of the virus in terms of structure, epidemiology, symptoms, treatment and prevention. Whole genome sequences and some viral proteins were investigated to determine gaps and changes in alternation of nucleotides and amino acid sequences. We evaluate 11 complete genome sequences of different coronaviruses using BAST and MAFFT software. We also selected seven types of structural proteins. We conclude that COVID-19 might produce new mutations, specifically in glycoproteins, so caution and complete preparation by health authorities is required.

Introduction

Novel coronavirus disease 19 (COVID-19) first emerged on 31 December 2019 in Wuhan city, China. COVID-19 is classified as the seventh member of the subfamily Orthocoronavirinae under the family Coronaviridae. Most members of this family are zoonotic viruses transmitted to humans through contact with infected animals. Although bats and snakes are the natural reservoir of most coronaviruses, there is no evidence so far that COVID-19 originated in or was transmitted from a seafood market [1]. Comparison of the lipid rafts of coronaviruses has indicated that the new strain COVID-19 has 80% identity with severe acute respiratory syndrome coronavirus (SARS-CoV). Lipid molecules such as caveolins, clathrins and dynamin have a fundamental role in the internalization of viruses. These molecules are involved in the entry of viruses into host cells, and targeting host lipids is being studied as an antiviral strategy and could have various applications [2]. COVID-19 seems to need to bind to the angiotensin-converting enzyme-2 receptor on the membrane host cell to enable it to infect the host cell upon coupled with a reliance of serine protease TMPRSS2. This intracellular protein seems to be a determinant of the virus ability to infect the cell [3].