بیماری زایی ایمنی مولکولی
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بیماری زایی ایمنی مولکولی

عنوان فارسی مقاله: بیماری زایی ایمنی مولکولی و تشخیص COVID-19
عنوان انگلیسی مقاله: Molecular immune pathogenesis and diagnosis of COVID-19
مجله/کنفرانس: مجله آنالیز دارویی – Journal of Pharmaceutical Analysis
رشته های تحصیلی مرتبط: پزشکی
گرایش های تحصیلی مرتبط: ویروس شناسی پزشکی، پزشکی مولکولی، ایمنی شناسی پزشکی یا ایمونولوژی، بیماری عفونی، اپیدمیولوژی یا همه گیر شناسی
کلمات کلیدی فارسی: کروناویروس، کروناویروس سارس ۲، کروناویروس سارس، کروناویروس مرس، بیماری زایی
کلمات کلیدی انگلیسی: Coronavirus، SARS-CoV-2، SARS-CoV، MERS-CoV، Pathogenesis
نوع نگارش مقاله: مقاله مروری (Review Article)
نمایه: Scopus – Master Journals List – JCR
شناسه دیجیتال (DOI): https://doi.org/10.1016/j.jpha.2020.03.001
دانشگاه: Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center, Xi’an, Shaanxi, 710061, China
ناشر: الزویر - Elsevier
نوع ارائه مقاله: ژورنال
نوع مقاله: ISI
سال انتشار مقاله: 2020
ایمپکت فاکتور: 4.842 در سال 2019
شاخص H_index: 21 در سال 2020
شاخص SJR: 0.763 در سال 2019
شناسه ISSN: 2095-1779
شاخص Quartile (چارک): Q2 در سال 2019
فرمت مقاله انگلیسی: PDF
تعداد صفحات مقاله انگلیسی: 7
وضعیت ترجمه: ترجمه نشده است
قیمت مقاله انگلیسی: رایگان
آیا این مقاله بیس است: خیر
آیا این مقاله مدل مفهومی دارد: ندارد
آیا این مقاله پرسشنامه دارد: ندارد
آیا این مقاله متغیر دارد: ندارد
کد محصول: E14865
رفرنس: دارای رفرنس در داخل متن و انتهای مقاله
فهرست انگلیسی مطالب

Abstract


Graphical abstract


۱٫ Introduction


۲٫ Virology of SARS-CoV-2


۳٫ Pathogenesis of COVID-19


۴٫ Diagnosis of COVID-19


۵٫ Current treatment strategies for COVID-19


۶٫ Conclusion


Conflicts of interest


Acknowledgments


Appendix A. Supplementary data


Research Data


References

نمونه متن انگلیسی مقاله

Abstract


Coronavirus disease 2019 (COVID-19) is a kind of viral pneumonia with an unusual outbreak in Wuhan, China, in December 2019, which is caused by severe acute respiratory syndrome coronavirus 2 (SARSCoV-2). The emergence of SARS-CoV-2 has been marked as the third introduction of a highly pathogenic coronavirus into the human population after the severe acute respiratory syndrome coronavirus (SARSCoV) and the Middle East respiratory syndrome coronavirus (MERS-CoV) in the twenty-first century. In this minireview, we provide a brief introduction of the general features of SARS-CoV-2 and discuss current knowledge of molecular immune pathogenesis, diagnosis and treatment of COVID-19 on the base of the present understanding of SARS-CoV and MERS-CoV infections, which may be helpful in offering novel insights and potential therapeutic targets for combating the SARS-CoV-2 infection.


Introduction


Novel coronavirus-induced pneumonia, which was named as coronavirus disease 2019 (COVID-19) by the WHO on the February 11, 2020, has rapidly increased in epidemic scale since it first appeared in Wuhan, China, in December 2019 [1]. On the same day, the international virus classification commission announced that the novel coronavirus was named as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 is not the first severe respiratory disease outbreak caused by the coronavirus. Just in the past two decades, coronaviruses have caused three epidemic diseases, namely, COVID-19, severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) [2]. At present, the cases of COVID-19 have been found in many countries around the world [3]. According to the latest data, up to the March 1, 2020, the number of confirmed cases in China reached 79,968, of which 2,873 were dead, and 41,681 were cured. In addition to China, the number of confirmed cases in other countries also reached 7,041, of which 105 were dead, and 459 were cured. On the 31st of January 2020, the World Health Organization (WHO) announced that COVID-19 was listed as the Public Health Emergency of International Concern (PHEIC), meaning that it may pose risks to multiple countries and requires a coordinated international response. The review tries to explain the molecular immune pathogenesis and diagnosis of COVID-19 and provide a reference for the prevention and drug development of SARS-CoV-2 infection, based on the recent research progress of SARS-CoV-2 and the knowledge from researches on SARS-CoV and MERS-CoV.

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