دانلود مقاله تأثیر بیماری کرون بر کودکان مبتلا به ADHD در دوران بارداری
چکیده
1. مقدمه
2. روش ها
3. نتایج
4. بحث
5. نتیجه گیری
منابع
Abstract
1. Introduction
2. Methods
3. Results
4. Discussion
5. Conclusion
Author contribution
Registration of research studies
Acknowledgement
References
چکیده
زمینه و هدف: کم خونی فقر آهن (IDA) یکی از عوارض شایع بیماری التهابی روده (IBD) در زنان باردار است. اگرچه مطالعات نشان داده اند که برخی از بیماری های خودایمنی مادر با اختلال نقص توجه و بیش فعالی (ADHD) در کودکان مرتبط است، هیچ مطالعه ای رابطه ای خاص بین و IDA در زنان باردار مبتلا به IBD و ADHD در فرزندانشان پیدا نکرده است. هدف این بررسی، شناسایی رابطه بین بیماری کرون مادر (CD) با IDA و ADHD در کودکان است.
مواد و روش‌ها: مروری بر ادبیات موجود با استفاده از PubMed برای جستجوی مقالات در مورد زنان باردار مبتلا به CD و IDA و کودکان مبتلا به ADHD انجام شد. این مطالعات شامل مطالعات مورد-شاهدی تودرتو، مطالعات کوهورت، مطالعات مقطعی، مطالعات مورد-شاهدی و مرور ادبیات منتشر شده از سال 2012 تا 2021 بود. نتایج: از بین 876 مقاله تولید شده، 11 مطالعه برای این مرور انتخاب شد. معیارهای ورود شامل هیچ مطالعه حیوانی، متاآنالیز یا مرور سیستماتیک و به دنبال آن موضوعات مرتبط با ADHD و CD و IDA مادر بود. یافته ها نشان می دهد که ADHD در فرزندان ممکن است به CD مادر نسبت داده شود. اگرچه هیچ مطالعه ای نشان نداده است که IDA در مادران مبتلا به CD با ADHD در فرزندان مرتبط است، اما چندین مطالعه همبستگی مثبتی را بین IDA مادر و ADHD در فرزندان نشان داده اند. برخی از مطالعات نشان می دهد که التهاب در IBD در دوران بارداری می تواند سیستم عصبی مرکزی را ملتهب کند و منجر به ADHD در فرزندان شود.
نتیجه گیری: IDA یک عارضه شایع در CD است و سطح ناکافی آهن با مشکلات رشد عصبی مانند ADHD مرتبط است. درمان با آهن برای مادران باردار مبتلا به CD برای جلوگیری از ADHD در فرزندان پیشنهاد می شود.
توجه! این متن ترجمه ماشینی بوده و توسط مترجمین ای ترجمه، ترجمه نشده است.
Abstract
Background
Iron deficiency anemia (IDA) is a common complication of inflammatory bowel disease (IBD) in pregnant women. Although studies have shown that certain maternal autoimmune diseases are associated with attention deficit hyperactivity disorder (ADHD) in children, no studies have found a relationship specifically between and IDA in pregnant women with IBD and ADHD in their children. This review aims identify a relationship between maternal Crohn's disease (CD) with IDA and ADHD in children.
Materials and methods
A review of existing literature was conducted using PubMed to search for articles on pregnant women with CD and IDA and children with ADHD. The studies included nested case-control studies, cohort studies, cross-sectional studies, case-control studies, and literature reviews published from 2012 to 2021.
Results
Among 876 articles generated, 11 studies were chosen for this review. Inclusion criteria consisted of no animal studies, meta-analysis or systematic reviews followed by ADHD related topics and maternal CD and IDA. The findings show that ADHD in progeny may be attributed to maternal CD. Although no studies have shown that IDA in mothers with CD is related to ADHD in offspring, several studies have shown a positive correlation between maternal IDA and ADHD in offspring. Some studies suggest inflammation in IBD during pregnancy can inflame the central nervous system, leading to ADHD in offspring.
Conclusion
IDA is a prevalent complication in CD, and inadequate iron levels are associated with neurodevelopmental problems, such as ADHD. Iron therapy for pregnant mothers diagnosed with CD is suggested to prevent ADHD in offspring.
Introduction
Attention deficit hyperactivity disorder (ADHD) is the most common neurodevelopmental disorder in childhood, affecting approximately 8.4% of US children between 2 and 17 years of age [1,2]. Symptoms of ADHD include losing items, disorganization, an inability to pay attention and concentrate, forgetting things quickly, and struggling to complete activities [2]. Evidence links the disorder's etiology to multiple factors, including genetics, environmental aspects and certain maternal autoimmune disorders such as psoriasis, rheumatoid arthritis, asthma and others [3,4].
Although studies have shown an association between certain maternal autoimmune diseases and ADHD in offspring, not much is known about how maternal inflammatory bowel diseases (IBDs), such as Crohn's disease (CD), affect neurodevelopment in progeny. It was recently estimated that approximately 1.5 million people have IBD, including ulcerative colitis, in the United States, causing considerable health and financial loss every year [5]. In most cases, the development of anemia is caused by iron deficiency, and results have shown that nearly 27% of people treated for CD have iron deficiency anemia (IDA) [4]. Furthermore, women with CD are at higher risk of anemia than men with CD possibly due to blood loss during menstruations [6].
Results
This review attempted to answer the question, “Is there a relationship between IDA in maternal CD and ADHD?” The search resulted in 11 studies (Appendix 1). These studies include 2 literature reviews [7,8], 4 cohort studies, 3 cross-sectional studies, 1 case-control study, and 1 nested case-control study.
3.1. Case-control studies
We found one case-control study [9] assessing the link between iron deficiency and ADHD in children (n = 630) from 5 to 18 years of age in Qatar. The findings indicated that mean ferritin levels were significantly lower in children with ADHD than in the control group (36.26 ± 5.93, 38.19 ± 5.61, respectively; p ≤ .01). Ferritin levels in children without ADHD were within the normal range. The researchers suggested that iron deficiency is linked to cognitive impairment, instability in psychomotor aspects in children, and difficulties in learning because of impairment within the central dopaminergic pathway. In summary, the study found that iron deficiency was strongly associated with ADHD symptoms, and these findings revealed the need for careful examination and possibly early intervention of iron supplementation in affected children to reduce the risk of ADHD.